Document Detail

Adverse reactions to dipyridamole in patients undergoing stress/rest cardiac perfusion testing.
MedLine Citation:
PMID:  11948263     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: A reaction scale was used to assess noncardiac adverse reactions exhibited by nuclear medicine outpatients receiving intravenous dipyridamole for pharmacological stress testing. METHODS: The study included 933 patients referred to 2 cardiac outpatient centers for assessment. All patients evaluated in this study were unable to perform treadmill stress testing and underwent pharmacological intravenous dipyridamole stress testing. Dual-isotope (201)Tl rest/(99m)Tc-sestamibi stress imaging was performed. An analysis of adverse reactions exhibited by patients given dipyridamole was tabulated. RESULTS: Of the 933 patients, 520 (55.7%) demonstrated no adverse reaction to intravenous dipyridamole; 413 patients (44.3%) had adverse reactions of some type. Many of these patients had multiple types of reactions, and a total of 604 reactions were recorded. The most prevalent adverse reaction was headache (224 reactions; 37.1%), followed by chest pain (73 reactions; 12.1%), and nausea (67 reactions; 11.1%). A sex comparison revealed 271 of 454 male patients (59.7%) and 249 of 479 female patients (52%) demonstrated no adverse reaction to intravenous dipyridamole. An evaluation of the most prevalent adverse reaction (headache) demonstrated a significant difference between males (37.9%) and females (62.1%). CONCLUSION: An adverse reaction scale characterizing common noncardiac side effects of dipyridamole in nuclear medicine cardiac patients demonstrated the most prevalent adverse reaction was headache. Analysis by sex revealed that significantly more females than males complained of headaches.
Art M Meyers; Lee Topham; Jim Ballow; David Totah; Reid Wilke
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of nuclear medicine technology     Volume:  30     ISSN:  0091-4916     ISO Abbreviation:  J Nucl Med Technol     Publication Date:  2002 Mar 
Date Detail:
Created Date:  2002-04-11     Completed Date:  2002-04-30     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0430303     Medline TA:  J Nucl Med Technol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  21-4     Citation Subset:  IM    
Department of Health Physics, University of Nevada, Las Vegas, Nevada 89154, USA.
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MeSH Terms
Chest Pain / chemically induced
Coronary Disease / radionuclide imaging*
Dipyridamole / adverse effects*,  diagnostic use
Exercise Test
Headache / chemically induced
Heart / radionuclide imaging*
Nausea / chemically induced
Radiopharmaceuticals / diagnostic use*
Retrospective Studies
Technetium Tc 99m Sestamibi / diagnostic use*
Thallium Radioisotopes / diagnostic use*
Tomography, Emission-Computed, Single-Photon*
Vasodilator Agents / adverse effects*,  diagnostic use
Reg. No./Substance:
0/Radiopharmaceuticals; 0/Thallium Radioisotopes; 0/Vasodilator Agents; 109581-73-9/Technetium Tc 99m Sestamibi; 58-32-2/Dipyridamole

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