Document Detail


Adverse prognostic influence of diabetes mellitus and hyperglycemia on the clinical course of cerebral infarction
MedLine Citation:
PMID:  1308381     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We accessed the potential impact of diabetes mellitus and hyperglycemia on early prognosis in a study of 109 cases of CT proved brain infarction. Main end-points of this study were 30-days case-fatality rates and the probability of early discharge or prolonged hospitalization. Proportions of patients exhibiting diverse evolutions were compared by Fisher's test and, when the number of observations permitted, by chi-square test. Diabetes mellitus was diagnosed by history in 15.6% (17 patients). In 86 cases analysed within 72 hours of admission, hyperglycemia (glucose level higher than 110 mg/dL) was detected in 67.4% (including all 14 diabetic patients (35.3% vs 21.7%; p = 0.18), but these patients probably were discharged early less frequently (23.5% vs 51.1%; p = 0.06). Compared to the normoglycemic patients, hyperglycemic patients also fared worse, when considering altogether the early discharge and case fatality rates and the need for prolonged hospitalization (p = 0.06). They also exhibited a nonsignificant increase in early case fatality rate (31% vs 15.4%; p = 0.21) and a markedly reduced chance of obtaining early hospital discharge (37.9% vs 65.4%; p = 0.03). Case fatality rates were maximal in diabetic hyperglycemic patients (42.9%) and seemed intermediate in non-diabetic hyperglycemic patients (27.3%). Considering the three end-points evaluated, the apparent differences between non-diabetic hyper and normoglycemic patients did not reach statistical significance (p = 0.19). These results suggest that both diabetes mellitus and hyperglycemia "per se" have deleterious effects on the clinical evolution of patients with cerebral infarction.(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
C André; S A Novis
Publication Detail:
Type:  English Abstract; Journal Article    
Journal Detail:
Title:  Arquivos de neuro-psiquiatria     Volume:  50     ISSN:  0004-282X     ISO Abbreviation:  Arq Neuropsiquiatr     Publication Date:  1992 Jun 
Date Detail:
Created Date:  1993-09-30     Completed Date:  1993-09-30     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0125444     Medline TA:  Arq Neuropsiquiatr     Country:  BRAZIL    
Other Details:
Languages:  por     Pagination:  147-50     Citation Subset:  IM    
Affiliation:
Serviço de Neurologia do Hospital Clementino Fraga Filho da Universidade Federal do Rio de Janeiro (HUCFF-UFRJ), Brasil.
Vernacular Title:
Influência prognóstica adversa do diabetes mellitus e da hiperglicemia sobre a evolução do infarto cerebral.
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MeSH Terms
Descriptor/Qualifier:
Adult
Blood Glucose / analysis
Cerebral Infarction / blood,  diagnosis,  etiology*,  mortality
Diabetic Angiopathies / blood,  diagnosis,  etiology*,  mortality
Female
Humans
Hyperglycemia / complications*
Length of Stay
Male
Prognosis
Tomography, X-Ray Computed
Chemical
Reg. No./Substance:
0/Blood Glucose

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