Document Detail

Adverse pregnancy outcomes in mothers with affective psychosis.
MedLine Citation:
PMID:  17430307     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: Affective psychosis has its peak incidence during the childbearing years, but little is known about the effects of the illness on pregnancy. We investigated risks of preterm delivery (PTD), low birthweight (LBW), births of infants small for their gestational age (SGA), stillbirth and infant death in births to mothers with affective psychosis using a nested case-control design within a cohort of 1,558,071 singleton births in Sweden during 1983-1997.
METHODS: Using prospectively collected data from population registers, we compared the pregnancy outcomes of 5,618 births to women with affective psychosis with the outcomes of 46,246 births to unaffected mothers.
RESULTS: Mothers with affective psychosis had elevated risk for giving birth to preterm, small or growth-retarded babies. The risk for stillbirth and infant death during the first year of life was not significantly higher. The risks were greatest in mothers receiving hospital treatment for affective disorder during pregnancy: (i) preterm delivery: odds ratio (OR) = 2.67, 95% confidence interval (CI) = 1.71-4.17; (ii) SGA: OR = 2.36; 95% CI = 1.34-4.16; (iii) low birthweight: OR = 2.22; 95% CI = 1.31-3.76; and (iv) stillbirth: OR = 2.19; 95% CI = 0.55-8.76. After adjustment for covariates, particularly smoking, the risks were attenuated but remained significant.
CONCLUSIONS: Clinicians should be aware of the increased risk of adverse pregnancy outcomes in women with affective psychosis, some of which may be preventable.
James H MacCabe; Lennart Martinsson; Paul Lichtenstein; Emma Nilsson; Sven Cnattingius; Robin M Murray; Christina M Hultman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Bipolar disorders     Volume:  9     ISSN:  1398-5647     ISO Abbreviation:  Bipolar Disord     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-04-13     Completed Date:  2007-07-10     Revised Date:  2014-02-19    
Medline Journal Info:
Nlm Unique ID:  100883596     Medline TA:  Bipolar Disord     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  305-9     Citation Subset:  IM    
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MeSH Terms
Case-Control Studies
Fetal Diseases / epidemiology
Fetal Growth Retardation / epidemiology
Infant, Newborn
Infant, Premature
Mothers / psychology*,  statistics & numerical data*
Pregnancy Complications / epidemiology*
Pregnancy Outcome*
Psychotic Disorders / diagnosis,  epidemiology*,  psychology*
Severity of Illness Index
Sweden / epidemiology
Grant Support
G106/1213//Medical Research Council

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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