| Adverse pregnancy outcomes are associated with multiple maternal thrombophilic factors. | |
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MedLine Citation:
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PMID: 15541848 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine to what extent adverse pregnancy outcomes are associated with thrombophilia. STUDY DESIGN: We studied 31 women who had HELLP syndrome, placental abruption, fetal growth restriction or unexplained stillbirth (study group), matched with 12 controls. All women were tested for: Factor V, Prothrombin, methylenetetrahydrofolate reductase gene (MTHFR) mutations; for Protein C, S and Antithrombin III deficiency; for lupus anticoagulant. Correlation with 24h BP monitoring and uterine Doppler velocimetry indexes at 22-24 weeks' gestation was performed. RESULTS: Women with multiple thrombophilic factors had a significant lower birth weight (1568.33+/-146.8 g versus 2546.45+/-438 g), higher 24 h mean diastolic blood pressure at second trimester (76.3+/-12.5 mmHg versus 65.2+/-7.8 mmHg) and higher RI of uterine arteries (0.69+/-0.05 versus 0.50+/-0.15) than women with single thrombophilic factor. CONCLUSION: Multiple thrombophilic factors carry a major additional risk for adverse maternal and fetal outcomes and correlate well with placental maladaptation as indicated by uterine Doppler velocimetry and 24h BP monitoring. |
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Authors:
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Andrea L Tranquilli; Stefano R Giannubilo; Bernardo Dell'Uomo; Elvira Grandone |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European journal of obstetrics, gynecology, and reproductive biology Volume: 117 ISSN: 0301-2115 ISO Abbreviation: Eur. J. Obstet. Gynecol. Reprod. Biol. Publication Date: 2004 Dec |
Date Detail:
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Created Date: 2004-11-15 Completed Date: 2005-04-08 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375672 Medline TA: Eur J Obstet Gynecol Reprod Biol Country: Ireland |
Other Details:
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Languages: eng Pagination: 144-7 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Polytechnic University of Marche, Salesi Hospital via Corridoni 11, 60123 Ancona, Italy. tranquilli@univpm.it |
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| MeSH Terms | |
Descriptor/Qualifier:
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Abruptio Placentae
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diagnosis,
etiology Adult Blood Pressure Monitoring, Ambulatory Female Fetal Growth Retardation / diagnosis, etiology HELLP Syndrome / diagnosis, etiology Humans Laser-Doppler Flowmetry Placenta Diseases / diagnosis Pregnancy Pregnancy Complications, Hematologic / diagnosis, etiology Pregnancy Outcome* Risk Factors Thrombophilia / complications*, diagnosis |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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