Document Detail


Adverse pregnancy outcomes are associated with multiple maternal thrombophilic factors.
MedLine Citation:
PMID:  15541848     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To determine to what extent adverse pregnancy outcomes are associated with thrombophilia. STUDY DESIGN: We studied 31 women who had HELLP syndrome, placental abruption, fetal growth restriction or unexplained stillbirth (study group), matched with 12 controls. All women were tested for: Factor V, Prothrombin, methylenetetrahydrofolate reductase gene (MTHFR) mutations; for Protein C, S and Antithrombin III deficiency; for lupus anticoagulant. Correlation with 24h BP monitoring and uterine Doppler velocimetry indexes at 22-24 weeks' gestation was performed. RESULTS: Women with multiple thrombophilic factors had a significant lower birth weight (1568.33+/-146.8 g versus 2546.45+/-438 g), higher 24 h mean diastolic blood pressure at second trimester (76.3+/-12.5 mmHg versus 65.2+/-7.8 mmHg) and higher RI of uterine arteries (0.69+/-0.05 versus 0.50+/-0.15) than women with single thrombophilic factor. CONCLUSION: Multiple thrombophilic factors carry a major additional risk for adverse maternal and fetal outcomes and correlate well with placental maladaptation as indicated by uterine Doppler velocimetry and 24h BP monitoring.
Authors:
Andrea L Tranquilli; Stefano R Giannubilo; Bernardo Dell'Uomo; Elvira Grandone
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of obstetrics, gynecology, and reproductive biology     Volume:  117     ISSN:  0301-2115     ISO Abbreviation:  Eur. J. Obstet. Gynecol. Reprod. Biol.     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2004-11-15     Completed Date:  2005-04-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375672     Medline TA:  Eur J Obstet Gynecol Reprod Biol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  144-7     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology, Polytechnic University of Marche, Salesi Hospital via Corridoni 11, 60123 Ancona, Italy. tranquilli@univpm.it
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MeSH Terms
Descriptor/Qualifier:
Abruptio Placentae / diagnosis,  etiology
Adult
Blood Pressure Monitoring, Ambulatory
Female
Fetal Growth Retardation / diagnosis,  etiology
HELLP Syndrome / diagnosis,  etiology
Humans
Laser-Doppler Flowmetry
Placenta Diseases / diagnosis
Pregnancy
Pregnancy Complications, Hematologic / diagnosis,  etiology
Pregnancy Outcome*
Risk Factors
Thrombophilia / complications*,  diagnosis

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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