Document Detail

Adverse pregnancy outcomes are associated with multiple maternal thrombophilic factors.
MedLine Citation:
PMID:  15541848     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine to what extent adverse pregnancy outcomes are associated with thrombophilia. STUDY DESIGN: We studied 31 women who had HELLP syndrome, placental abruption, fetal growth restriction or unexplained stillbirth (study group), matched with 12 controls. All women were tested for: Factor V, Prothrombin, methylenetetrahydrofolate reductase gene (MTHFR) mutations; for Protein C, S and Antithrombin III deficiency; for lupus anticoagulant. Correlation with 24h BP monitoring and uterine Doppler velocimetry indexes at 22-24 weeks' gestation was performed. RESULTS: Women with multiple thrombophilic factors had a significant lower birth weight (1568.33+/-146.8 g versus 2546.45+/-438 g), higher 24 h mean diastolic blood pressure at second trimester (76.3+/-12.5 mmHg versus 65.2+/-7.8 mmHg) and higher RI of uterine arteries (0.69+/-0.05 versus 0.50+/-0.15) than women with single thrombophilic factor. CONCLUSION: Multiple thrombophilic factors carry a major additional risk for adverse maternal and fetal outcomes and correlate well with placental maladaptation as indicated by uterine Doppler velocimetry and 24h BP monitoring.
Andrea L Tranquilli; Stefano R Giannubilo; Bernardo Dell'Uomo; Elvira Grandone
Related Documents :
11110338 - Single umbilical artery is associated with an increased incidence of structural and chr...
3618248 - Serum cortisol level changes in the maternal-fetoplacental unit between the 28th-40th w...
9595368 - Umbilical arterial flow change during hemodialysis.
16280208 - Arterial and venous doppler in the diagnosis and management of early onset fetal growth...
25188078 - Gynecologic pathology: sy12-3 immunohistochemical and molecular adjunct techniques in d...
21684558 - Early versus late maturation arrest: reproductive outcomes of testicular failure.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of obstetrics, gynecology, and reproductive biology     Volume:  117     ISSN:  0301-2115     ISO Abbreviation:  Eur. J. Obstet. Gynecol. Reprod. Biol.     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2004-11-15     Completed Date:  2005-04-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375672     Medline TA:  Eur J Obstet Gynecol Reprod Biol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  144-7     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Polytechnic University of Marche, Salesi Hospital via Corridoni 11, 60123 Ancona, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Abruptio Placentae / diagnosis,  etiology
Blood Pressure Monitoring, Ambulatory
Fetal Growth Retardation / diagnosis,  etiology
HELLP Syndrome / diagnosis,  etiology
Laser-Doppler Flowmetry
Placenta Diseases / diagnosis
Pregnancy Complications, Hematologic / diagnosis,  etiology
Pregnancy Outcome*
Risk Factors
Thrombophilia / complications*,  diagnosis

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Incidence of toxoplasmosis in 5532 pregnant women in Crete, Greece: management of 185 cases at risk.
Next Document:  Symmetrical fetal growth retardation after gestational cocaine exposure in the rat.