Document Detail

Adverse periocular reactions to five types of prostaglandin analogs.
MedLine Citation:
PMID:  23037910     Owner:  NLM     Status:  MEDLINE    
PURPOSE: We investigated the appearance frequency of eyelid pigmentation and eyelash bristles after the use of five types of prostaglandin (PG) analogs.
METHODS: This study included 250 eyes from 250 patients diagnosed with primary open-angle glaucoma or ocular hypertension who were treated with either latanoprost, travoprost, tafluprost, bimatoprost, or isopropyl unoprostone for >3 months in only one eye. Photographs of both eyes were obtained, and the images were assessed by three ophthalmologists who were masked to treatment type. The existence of eyelid pigmentation and eyelash bristles was judged, and images of the left and right eyes were compared. Subjective symptoms regarding the existence of eyelid pigmentation and eyelash bristles were investigated through a questionnaire.
RESULTS: There was no significant difference between the five types of medications with regard to eyelid pigmentation (P=0.537). Use of isopropyl unoprostone resulted in a significantly lower incidence of eyelash bristles (P<0.0001). The questionnaire investigation showed that eyelid pigmentation and eyelash bristles were significantly more frequent with travoprost (42.0% and 42.0%, respectively) and bimatoprost (58.0% and 60.0%, respectively) than with other three medications (P<0.0001).
CONCLUSION: The appearance frequency of eyelid pigmentation was similar among the five types of PG analogs studied, and eyelash bristles appeared less frequently with isopropyl unoprostone use. Patients are conscious of eyelash bristles; therefore, these adverse effects should be sufficiently explained to patients before PG administration.
K Inoue; M Shiokawa; R Higa; M Sugahara; T Soga; M Wakakura; G Tomita
Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2012-10-05
Journal Detail:
Title:  Eye (London, England)     Volume:  26     ISSN:  1476-5454     ISO Abbreviation:  Eye (Lond)     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-08     Completed Date:  2013-05-15     Revised Date:  2013-11-05    
Medline Journal Info:
Nlm Unique ID:  8703986     Medline TA:  Eye (Lond)     Country:  England    
Other Details:
Languages:  eng     Pagination:  1465-72     Citation Subset:  IM    
Inouye Eye Hospital, Tokyo, Japan.
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MeSH Terms
Aged, 80 and over
Amides / adverse effects
Antihypertensive Agents / adverse effects*
Cloprostenol / adverse effects,  analogs & derivatives
Dinoprost / adverse effects,  analogs & derivatives
Eyelashes / drug effects*
Eyelid Diseases / chemically induced*
Glaucoma, Open-Angle / drug therapy*
Intraocular Pressure / drug effects
Middle Aged
Ocular Hypertension / drug therapy
Prospective Studies
Prostaglandins F / adverse effects
Prostaglandins F, Synthetic / adverse effects
Prostaglandins, Synthetic / adverse effects*
Skin Pigmentation / drug effects*
Reg. No./Substance:
0/Amides; 0/Antihypertensive Agents; 0/Prostaglandins F; 0/Prostaglandins F, Synthetic; 0/Prostaglandins, Synthetic; 0/bimatoprost; 130209-82-4/latanoprost; 157283-68-6/travoprost; 1O6WQ6T7G3/tafluprost; 40665-92-7/Cloprostenol; 551-11-1/Dinoprost; 69553-75-9/isopropyl unoprostone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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