Document Detail

Adverse neurodevelopmental outcome of infants exposed to opiate in-utero.
MedLine Citation:
PMID:  17728081     Owner:  NLM     Status:  MEDLINE    
In-utero drug exposure is associated with increased risks of perinatal morbidity and mortality, however longer term neurodevelopmental outcome of survivors is poorly described. AIMS: The aims of this paper are: (1) to review the published literature which examines neurodevelopmental outcome in infants with Neonatal Abstinence Syndrome (NAS) and (2) to report developmental follow-up data from a case-control study of babies exposed to opiate in-utero. METHODS: This study was conducted at Royal Prince Alfred Hospital in Sydney, NSW, through the multidisciplinary NAS service. Literature was reviewed after searching MEDLINE for relevant studies. Our own case-control study was conducted to examine neurodevelopmental outcome. A number of standardized neuropsychological tools were employed to assess these infants. RESULTS: Results from previously published studies on outcome of infants with NAS were not reassuring as to reported 'normal development'. In our own case-control study, opiate-exposed infants were significantly more likely to have neurodevelopmental impairment compared to healthy control infants, when assessed at 18 months and 3 years of age. CONCLUSIONS: Infants exposed to opiates in-utero are at increased risk of neurodevelopmental problems throughout early childhood.
Rod W Hunt; Dimitra Tzioumi; Edith Collins; Heather E Jeffery
Publication Detail:
Type:  Journal Article     Date:  2007-08-28
Journal Detail:
Title:  Early human development     Volume:  84     ISSN:  0378-3782     ISO Abbreviation:  Early Hum. Dev.     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2008-01-11     Completed Date:  2008-04-03     Revised Date:  2009-04-16    
Medline Journal Info:
Nlm Unique ID:  7708381     Medline TA:  Early Hum Dev     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  29-35     Citation Subset:  IM    
Department of Neonatal Medicine, The Royal Children's Hospital, Parkville, VIC, Australia.
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MeSH Terms
Case-Control Studies
Child, Preschool
Developmental Disabilities / chemically induced*,  physiopathology,  psychology
Follow-Up Studies
Infant, Newborn
Maternal Exposure / adverse effects*
Neonatal Abstinence Syndrome / etiology*,  physiopathology,  psychology
Nervous System Diseases / chemically induced*,  physiopathology,  psychology
Opioid-Related Disorders / physiopathology*
Prenatal Exposure Delayed Effects*
Comment In:
Early Hum Dev. 2009 Apr;85(4):271-2   [PMID:  19008056 ]

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