Document Detail

Adverse long-term effects of brain radiotherapy in adult low-grade glioma patients.
MedLine Citation:
PMID:  11376174     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To study the long-term effects of radiotherapy on cognitive function in adult patients operated on for low-grade glioma. METHODS: A cohort of 160 patients who underwent surgery for low-grade gliomas of cerebral hemisphere between 1980 and 1992 in a single institution serving a defined population was studied. At a mean follow-up time of 7 years, 28 of the 101 patients who had postoperative irradiation (and no second surgery or chemotherapy) were still alive and eligible for MRI and neuropsychological study. Twenty-three of 59 patients who did not have radiotherapy, second surgery, or chemotherapy were alive and eligible at a mean of 10 years. RESULTS: The group that had postoperative irradiation performed significantly worse than the group that did not in cognitive tests. This difference was not accounted for by histologic diagnosis; location, extent of removal, or progression of the tumor; or any patient factor. Leukoencephalopathy was more severe in the group that had postoperative irradiation than in the group without radiotherapy, and correlated to poor memory performances only in the postoperative radiotherapy group. Average Karnofsky performance scale score was significantly lower in the group that had postoperative irradiation than in the group that did not. CONCLUSION: In adults with low-grade glioma, postoperative radiotherapy poses a significant risk of long-term leukoencephalopathy and cognitive impairment.
O Surma-aho; M Niemelä; J Vilkki; M Kouri; A Brander; O Salonen; A Paetau; M Kallio; J Pyykkönen ; J Jääskeläinen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neurology     Volume:  56     ISSN:  0028-3878     ISO Abbreviation:  Neurology     Publication Date:  2001 May 
Date Detail:
Created Date:  2001-05-28     Completed Date:  2001-06-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1285-90     Citation Subset:  AIM; IM    
Department of Neurosurgery, Helsinki University Hospital, Finland.
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MeSH Terms
Brain Neoplasms / pathology,  physiopathology,  radiotherapy*
Cognition Disorders / pathology,  physiopathology,  psychology
Cohort Studies
Disease Progression
Follow-Up Studies
Functional Laterality / physiology
Glioma / pathology,  physiopathology,  radiotherapy*
Magnetic Resonance Imaging
Neuropsychological Tests
Time Factors
Treatment Outcome
Comment In:
Neurology. 2001 May 22;56(10):1255-6   [PMID:  11376168 ]
Neurology. 2001 Dec 11;57(11):2150-1   [PMID:  11739855 ]

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