Document Detail

Adverse haemodynamic effects of the rapid intravenous injection of hypotonic solutions in sheep.
MedLine Citation:
PMID:  8735508     Owner:  NLM     Status:  MEDLINE    
The rapid intravenous administration of 10 ml of sterile water or hypotonic saline to five conscious sheep induced substantial adverse haemodynamic effects lasting 10 to 20 seconds. They included reductions in cardiac output (to 44 per cent of the baseline value measured in the 30 seconds before the injection), arterial blood pressure (67 per cent of baseline), left ventricular systolic pressure (60 per cent of baseline), myocardial contractility (60 per cent of baseline), and left coronary arterial blood flow (39 per cent of baseline), and increases in heart rate to 137 per cent of the baseline. The intensities of these effects were related directly to the rates of injection and inversely to the osmolalities of the solutions injected. Intravascular haemolysis was associated with the effects. These data are of potential importance to anyone administering drugs intravenously to sheep.
Y F Huang; R N Upton; A J Rutten
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Research in veterinary science     Volume:  60     ISSN:  0034-5288     ISO Abbreviation:  Res. Vet. Sci.     Publication Date:  1996 May 
Date Detail:
Created Date:  1997-03-18     Completed Date:  1997-03-18     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0401300     Medline TA:  Res Vet Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  209-12     Citation Subset:  IM    
Department of Anaesthesia and Intensive Care, Royal Adelaide Hospital, University of Adelaide, Australia.
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MeSH Terms
Blood Pressure
Cardiac Output
Coronary Circulation
Heart Rate
Hypotonic Solutions / administration & dosage*,  adverse effects
Injections, Intravenous / methods,  veterinary*
Sodium Chloride / administration & dosage*,  adverse effects
Time Factors
Reg. No./Substance:
0/Hypotonic Solutions; 7647-14-5/Sodium Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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