| Adverse haemodynamic effects of the rapid intravenous injection of hypotonic solutions in sheep. | |
| | |
MedLine Citation:
|
PMID: 8735508 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The rapid intravenous administration of 10 ml of sterile water or hypotonic saline to five conscious sheep induced substantial adverse haemodynamic effects lasting 10 to 20 seconds. They included reductions in cardiac output (to 44 per cent of the baseline value measured in the 30 seconds before the injection), arterial blood pressure (67 per cent of baseline), left ventricular systolic pressure (60 per cent of baseline), myocardial contractility (60 per cent of baseline), and left coronary arterial blood flow (39 per cent of baseline), and increases in heart rate to 137 per cent of the baseline. The intensities of these effects were related directly to the rates of injection and inversely to the osmolalities of the solutions injected. Intravascular haemolysis was associated with the effects. These data are of potential importance to anyone administering drugs intravenously to sheep. |
| | |
Authors:
|
Y F Huang; R N Upton; A J Rutten |
Related Documents
:
|
22062658 - Lipid oxidation of pressurized and cooked chicken: role of sodium chloride and mechanic... 803058 - Subendocardial s-t segment changes during acute coronary occlusion. 21143998 - Relationship of 24-hour ambulatory blood pressure and heart rate with markers of hepati... 18607168 - The association of elasticity indexes of ascending aorta and the presence and the sever... 8432288 - Paradoxical decrease in circulating neuropeptide y-like immunoreactivity during mild or... 7464088 - Development of a twin-flap, porous ceramic mitral valve prosthesis. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Research in veterinary science Volume: 60 ISSN: 0034-5288 ISO Abbreviation: Res. Vet. Sci. Publication Date: 1996 May |
Date Detail:
|
Created Date: 1997-03-18 Completed Date: 1997-03-18 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0401300 Medline TA: Res Vet Sci Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 209-12 Citation Subset: IM |
Affiliation:
|
Department of Anaesthesia and Intensive Care, Royal Adelaide Hospital, University of Adelaide, Australia. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Blood Pressure Cardiac Output Coronary Circulation Diastole Female Heart Rate Hemodynamics* Hypotonic Solutions / administration & dosage*, adverse effects Injections, Intravenous / methods, veterinary* Sheep Sodium Chloride / administration & dosage*, adverse effects Systole Time Factors |
| Chemical | |
Reg. No./Substance:
|
0/Hypotonic Solutions; 7647-14-5/Sodium Chloride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Adrenocortical function in the domestic cat during treatment with levonorgestrel.
Next Document: Pharmacokinetics of propofol infusions, either alone or with ketamine, in sheep premedicated with ac...