| Adverse events in peripheral progenitor cell collection: a 7-year experience. | |
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MedLine Citation:
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PMID: 11672514 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Collection of peripheral progenitor cells (PPC) by apheresis machines is generally regarded as a safe procedure. However, data about adverse events in PPC harvesting are scarce. In a monocentric retrospective study, the data of 540 PPC collections in a period of 7 years were reviewed. Adverse events were subdivided in collection-associated technical problems and patient/donor-related side effects. Patient/donor-related side effects occurred most often (19.8%); most of them were paresthesias due to citrate toxicity. Paresthesias were treated by oral (20.4%) or intravenous (1.1%) calcium supplementation. Problems with venous access were also seen frequently, resulting in blood flow alarms (11.3%) and blockades in the return line (4.3%). A total of 6.9% of these problems were catheter associated, requiring revision of the central venous line in 2.6%. Technical problems with the blood cell separators were observed in 11.7%. Ten PPC collections were discontinued due to adverse events. The data of this retrospective, monocentric analysis show that patient/donor-associated problems were observed in every fifth PPC harvest. Most of them were paresthesias, which could be easily treated by calcium supplementation. Problems with venous access and technical problems with the cell separators occurred in every tenth PPC collection. |
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Authors:
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R Moog |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of hematotherapy & stem cell research Volume: 10 ISSN: 1525-8165 ISO Abbreviation: J. Hematother. Stem Cell Res. Publication Date: 2001 Oct |
Date Detail:
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Created Date: 2001-10-23 Completed Date: 2002-01-11 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 100892915 Medline TA: J Hematother Stem Cell Res Country: United States |
Other Details:
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Languages: eng Pagination: 675-80 Citation Subset: IM |
Affiliation:
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Institute for Transfusion Medicine, University Clinics Essen, Germany. rainer.moog@uni-essen.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Blood Cell Count Blood Component Removal / adverse effects*, instrumentation, statistics & numerical data Blood Donors Catheterization / adverse effects Child Child, Preschool Hematoma / etiology Hematopoietic Stem Cell Mobilization Hematopoietic Stem Cell Transplantation Hematopoietic Stem Cells / cytology* Hemorrhage / etiology Humans Hypotension / etiology Infant Middle Aged Pain / etiology Paresthesia / etiology Phlebotomy / adverse effects Retrospective Studies Vomiting / etiology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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