Document Detail

Adverse events associated with psychotropic treatment in African American children and adolescents.
MedLine Citation:
PMID:  20533772     Owner:  NLM     Status:  MEDLINE    
To identify the types of adverse events associated with psychotropic treatment in African American children and adolescents, analyses were performed using a retrospective cohort design evaluating medical and pharmacy claims from South Carolina's Medicaid program covering outpatient and inpatient medical services and medication prescriptions between January 1996 and December 2005. All children and adolescents prescribed 1 of 7 antipsychotic medications, 1 of 26 antidepressants, or 1 of 3 antimanic agents, and a random sample of 4500 children not treated with psychotropic medications were identified. Antipsychotics were more closely associated with the development of obesity and sexual/reproductive adverse events in African American patients. In the antidepressant-treated cohort, incident obesity/weight gain, dyslipidemia, and type 2 diabetes mellitus were more likely in African American patients. Obesity/weight gain, dyslipidemia, and sexual/reproductive problems were significantly more likely for African American patients treated with antimanic agents. Practitioners need to carefully weigh the risks/benefits of prescribing all types of psychotropic agents to African American children, taking into consideration preexisting/comorbid conditions or individual risk factors for adverse reactions, especially when multiple medications are prescribed.
Jeanette M Jerrell
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of the National Medical Association     Volume:  102     ISSN:  0027-9684     ISO Abbreviation:  J Natl Med Assoc     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-06-10     Completed Date:  2010-07-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7503090     Medline TA:  J Natl Med Assoc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  375-83     Citation Subset:  IM    
Department of Neuropsychiatry and Behavioral Science, University of South Carolina School of Medicine, 3555 Harden St Ext, 15 Medical Park, Ste 301, Columbia, SC 29203, USA.
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MeSH Terms
Diabetes Mellitus, Type 2 / ethnology,  etiology
Drug Prescriptions / economics,  statistics & numerical data
Dyslipidemias / ethnology,  etiology
Follow-Up Studies
Medical Assistance / statistics & numerical data
Obesity / ethnology,  etiology
Prescription Drugs / adverse effects,  economics
Psychotic Disorders / drug therapy*,  ethnology
Psychotropic Drugs / adverse effects*,  economics,  therapeutic use
Retrospective Studies
Risk Factors
Sexual Dysfunction, Physiological / ethnology,  etiology
South Carolina / epidemiology
Grant Support
Reg. No./Substance:
0/Prescription Drugs; 0/Psychotropic Drugs

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