| Adverse events associated with psychotropic treatment in African American children and adolescents. | |
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MedLine Citation:
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PMID: 20533772 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To identify the types of adverse events associated with psychotropic treatment in African American children and adolescents, analyses were performed using a retrospective cohort design evaluating medical and pharmacy claims from South Carolina's Medicaid program covering outpatient and inpatient medical services and medication prescriptions between January 1996 and December 2005. All children and adolescents prescribed 1 of 7 antipsychotic medications, 1 of 26 antidepressants, or 1 of 3 antimanic agents, and a random sample of 4500 children not treated with psychotropic medications were identified. Antipsychotics were more closely associated with the development of obesity and sexual/reproductive adverse events in African American patients. In the antidepressant-treated cohort, incident obesity/weight gain, dyslipidemia, and type 2 diabetes mellitus were more likely in African American patients. Obesity/weight gain, dyslipidemia, and sexual/reproductive problems were significantly more likely for African American patients treated with antimanic agents. Practitioners need to carefully weigh the risks/benefits of prescribing all types of psychotropic agents to African American children, taking into consideration preexisting/comorbid conditions or individual risk factors for adverse reactions, especially when multiple medications are prescribed. |
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Authors:
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Jeanette M Jerrell |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of the National Medical Association Volume: 102 ISSN: 0027-9684 ISO Abbreviation: J Natl Med Assoc Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-06-10 Completed Date: 2010-07-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7503090 Medline TA: J Natl Med Assoc Country: United States |
Other Details:
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Languages: eng Pagination: 375-83 Citation Subset: IM |
Affiliation:
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Department of Neuropsychiatry and Behavioral Science, University of South Carolina School of Medicine, 3555 Harden St Ext, 15 Medical Park, Ste 301, Columbia, SC 29203, USA. jeanette.jerrell@uscmed.sc.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Child Diabetes Mellitus, Type 2 / ethnology, etiology Drug Prescriptions / economics, statistics & numerical data Dyslipidemias / ethnology, etiology Female Follow-Up Studies Humans Incidence Male Medical Assistance / statistics & numerical data Obesity / ethnology, etiology Prescription Drugs / adverse effects, economics Prevalence Psychotic Disorders / drug therapy*, ethnology Psychotropic Drugs / adverse effects*, economics, therapeutic use Retrospective Studies Risk Factors Sexual Dysfunction, Physiological / ethnology, etiology South Carolina / epidemiology |
| Grant Support | |
ID/Acronym/Agency:
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SM54192/SM/CMHS SAMHSA HHS |
| Chemical | |
Reg. No./Substance:
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0/Prescription Drugs; 0/Psychotropic Drugs |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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