| Adverse event rates following primary PCI for STEMI at US and non-US hospitals: three-year analysis from the HORIZONS-AMI trial. | |
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MedLine Citation:
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PMID: 23425539 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Aims: To examine outcomes in patients with ST-segment elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (PCI) at US sites versus sites outside the US (OUS). Methods and results: In the HORIZONS-AMI trial 3,602 STEMI patients in 11 countries were randomised to primary PCI with bivalirudin versus heparin + glycoprotein IIb/IIIa inhibitors. US patients (n=814) had more diabetes, prior infarction, prior bypass surgery, and renal insufficiency. OUS patients (n=2,788) had longer door-to-balloon times, more radial access, fewer bypass surgeries, and were discharged more often on beta-blockers and statins. At three years US patients had higher mortality (9.7% vs. 6.0%, p=0.0003), reinfarction (10.2% vs. 6.4%, p=0.001), major adverse cardiac events (MACE; 28.2% vs. 20.1%, p<0.0001), major bleeding (16.9% vs. 6.4%, p<0.0001) and net adverse clinical events (NACE; 36.6% vs. 23.8%, p<0.0001), which persisted after adjusting for baseline risk. Conclusions: In the HORIZONS-AMI trial, STEMI patients undergoing primary PCI at US versus OUS sites had higher rates of adverse events, which persisted after adjusting for baseline risk. The reasons for these differences are not clear but may be due to unmeasured confounders, different thresholds for event reporting, or valid differences in systems of care and treatments. Registration: ClinicalTrials.gov number NCT00433966. |
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Authors:
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Patrick Tobbia; Bruce R Brodie; Bernhard Witzenbichler; Chris Metzger; Giulio Guagliumi; Jennifer Yu; Mirle A Kellett; Thomas Stuckey; Martin Fahy; Roxana Mehran; Gregg W Stone |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology Volume: 8 ISSN: 1969-6213 ISO Abbreviation: EuroIntervention Publication Date: 2013 Feb |
Date Detail:
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Created Date: 2013-02-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101251040 Medline TA: EuroIntervention Country: France |
Other Details:
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Languages: eng Pagination: 1134-42 Citation Subset: IM |
Affiliation:
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LeBauer Cardiovascular Research Foundation and Moses Cone Hospital, Greensboro, NC, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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