Document Detail

Adverse effects of three different forms of heparin therapy: thrombocytopenia, increased transaminases, and hyperkalaemia.
MedLine Citation:
PMID:  2557219     Owner:  NLM     Status:  MEDLINE    
A prospective study has been made of the incidence of changes in transaminase levels, hyperkalaemia and thrombocytopenia in three groups of patients: 89 consecutive patients with venous thrombosis receiving therapeutic heparinization, 49 patients admitted because of hip fracture and receiving prophylactic low-dose conventional heparin, and 43 patients admitted because of hip fracture and randomly allocated to receive low molecular weight heparin. Laboratory measurements were made on admission and 8 days after commencing heparin. Only two patients on high-dose heparin developed thrombocytopenia. Increased transaminases were frequent with conventional heparin (18% and 32% of patients on high-dose heparin developed abnormal AsT and AlT values, respectively compared with 14% and 17% patients on low dose therapy). In contrast, only one patient on low molecular weight heparin developed abnormal AlT activity. Hyperkalaemia was uncommon in patients on any form of heparin therapy, and severe hyperkalaemia occurred in only one patient.
M Monreal; E Lafoz; R Salvador; J Roncales; A Navarro
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  European journal of clinical pharmacology     Volume:  37     ISSN:  0031-6970     ISO Abbreviation:  Eur. J. Clin. Pharmacol.     Publication Date:  1989  
Date Detail:
Created Date:  1990-02-02     Completed Date:  1990-02-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  1256165     Medline TA:  Eur J Clin Pharmacol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  415-8     Citation Subset:  IM    
Hospital de Badalona Germans trias i Pujol, Facultad de Medicina, Universidad Autónoma de Barcelona, Spain.
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MeSH Terms
Aged, 80 and over
Alanine Transaminase / blood*
Aspartate Aminotransferases / blood*
Clinical Protocols
Heparin / adverse effects*,  therapeutic use
Heparin, Low-Molecular-Weight / adverse effects*,  therapeutic use
Hip Fractures
Hyperkalemia / chemically induced*
Middle Aged
Prospective Studies
Random Allocation
Thrombocytopenia / chemically induced*
Thrombophlebitis / drug therapy
Reg. No./Substance:
0/Heparin, Low-Molecular-Weight; 9005-49-6/Heparin; EC Aminotransferases; EC Transaminase

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