Document Detail

Adverse effects of three different forms of heparin therapy: thrombocytopenia, increased transaminases, and hyperkalaemia.
MedLine Citation:
PMID:  2557219     Owner:  NLM     Status:  MEDLINE    
A prospective study has been made of the incidence of changes in transaminase levels, hyperkalaemia and thrombocytopenia in three groups of patients: 89 consecutive patients with venous thrombosis receiving therapeutic heparinization, 49 patients admitted because of hip fracture and receiving prophylactic low-dose conventional heparin, and 43 patients admitted because of hip fracture and randomly allocated to receive low molecular weight heparin. Laboratory measurements were made on admission and 8 days after commencing heparin. Only two patients on high-dose heparin developed thrombocytopenia. Increased transaminases were frequent with conventional heparin (18% and 32% of patients on high-dose heparin developed abnormal AsT and AlT values, respectively compared with 14% and 17% patients on low dose therapy). In contrast, only one patient on low molecular weight heparin developed abnormal AlT activity. Hyperkalaemia was uncommon in patients on any form of heparin therapy, and severe hyperkalaemia occurred in only one patient.
M Monreal; E Lafoz; R Salvador; J Roncales; A Navarro
Related Documents :
11218679 - Prothrombotic factors in nephrotic syndrome.
20956709 - Patient-level meta-analysis: effect of measurement timing, threshold, and patient age o...
12747279 - Link between anti-cd36 antibodies and thrombosis in the antiphospholipid syndrome.
9526949 - Evaluation of the combination of a bedside d-dimer assay and enzyme-linked immunosorben...
5943339 - Venous distensibility in patients with varicose veins.
11796959 - Effect of tissue injury on d-dimer levels: a prospective study in trauma patients.
2104719 - Radiographic detection of esophageal malpositioning of endotracheal tubes.
25493089 - Effects of a rivastigmine patch on self-care activities in patients with alzheimer's di...
9071079 - Nontraumatic perforations of the small intestine.
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  European journal of clinical pharmacology     Volume:  37     ISSN:  0031-6970     ISO Abbreviation:  Eur. J. Clin. Pharmacol.     Publication Date:  1989  
Date Detail:
Created Date:  1990-02-02     Completed Date:  1990-02-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  1256165     Medline TA:  Eur J Clin Pharmacol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  415-8     Citation Subset:  IM    
Hospital de Badalona Germans trias i Pujol, Facultad de Medicina, Universidad Autónoma de Barcelona, Spain.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Aged, 80 and over
Alanine Transaminase / blood*
Aspartate Aminotransferases / blood*
Clinical Protocols
Heparin / adverse effects*,  therapeutic use
Heparin, Low-Molecular-Weight / adverse effects*,  therapeutic use
Hip Fractures
Hyperkalemia / chemically induced*
Middle Aged
Prospective Studies
Random Allocation
Thrombocytopenia / chemically induced*
Thrombophlebitis / drug therapy
Reg. No./Substance:
0/Heparin, Low-Molecular-Weight; 9005-49-6/Heparin; EC Aminotransferases; EC Transaminase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  New in vivo model to assess venous endothelial cell functions. Effect of defibrotide.
Next Document:  Decreased plasma membrane fluidity of peripheral blood lymphocytes after diethyldithiocarbamate (DTC...