Document Detail

Adverse effects of proton pump inhibitors.
MedLine Citation:
PMID:  20227032     Owner:  NLM     Status:  MEDLINE    
Proton pump inhibitors (PPI) are very effective drugs used largely in acid related disorders. During the last years concern have been raised regarding their overutilisation in benign condition, such as gastroesophageal reflux disease. The debate focussed also on the risk of adverse events related to long term use of PPI. Apart of the case of Helicobacter Pylori (H. Pylori) positive patients, in whose long term acid suppression lead to the development of corpus predominant atrophic gastritis, precursor of cancer; the other assumed adverse events, have never been demonstrated in prospective studies. The attention should move towards the appropriate prescription of PPI, rather than the fear adverse effects of PPI. In fact, in clinical practise, PPI are often prescribed in patients without a specific acid related disease and continued long term based on their safety profile. This review focus on the main adverse events related to long term PPI use.
Francesca Lodato; Francesco Azzaroli; Laura Turco; Natalia Mazzella; Federica Buonfiglioli; Marco Zoli; Giuseppe Mazzella
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Best practice & research. Clinical gastroenterology     Volume:  24     ISSN:  1532-1916     ISO Abbreviation:  Best Pract Res Clin Gastroenterol     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-03-15     Completed Date:  2010-06-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101120605     Medline TA:  Best Pract Res Clin Gastroenterol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  193-201     Citation Subset:  IM    
Copyright Information:
Copyright 2009 Elsevier Ltd. All rights reserved.
Department of Internal Medicine and Gastroenterology, University of Bologna, Bologna, Italy.
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MeSH Terms
Fractures, Bone / chemically induced
Gastroenteritis / chemically induced,  microbiology
Magnesium Deficiency / chemically induced
Polyps / chemically induced
Proton Pump Inhibitors / adverse effects*
Risk Assessment
Risk Factors
Stomach Neoplasms / chemically induced
Vitamin B 12 Deficiency / chemically induced
Reg. No./Substance:
0/Proton Pump Inhibitors

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