| Adverse effects of proton pump inhibitors. | |
| | |
MedLine Citation:
|
PMID: 20227032 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Proton pump inhibitors (PPI) are very effective drugs used largely in acid related disorders. During the last years concern have been raised regarding their overutilisation in benign condition, such as gastroesophageal reflux disease. The debate focussed also on the risk of adverse events related to long term use of PPI. Apart of the case of Helicobacter Pylori (H. Pylori) positive patients, in whose long term acid suppression lead to the development of corpus predominant atrophic gastritis, precursor of cancer; the other assumed adverse events, have never been demonstrated in prospective studies. The attention should move towards the appropriate prescription of PPI, rather than the fear adverse effects of PPI. In fact, in clinical practise, PPI are often prescribed in patients without a specific acid related disease and continued long term based on their safety profile. This review focus on the main adverse events related to long term PPI use. |
| | |
Authors:
|
Francesca Lodato; Francesco Azzaroli; Laura Turco; Natalia Mazzella; Federica Buonfiglioli; Marco Zoli; Giuseppe Mazzella |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: Best practice & research. Clinical gastroenterology Volume: 24 ISSN: 1532-1916 ISO Abbreviation: Best Pract Res Clin Gastroenterol Publication Date: 2010 Apr |
Date Detail:
|
Created Date: 2010-03-15 Completed Date: 2010-06-03 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101120605 Medline TA: Best Pract Res Clin Gastroenterol Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 193-201 Citation Subset: IM |
Copyright Information:
|
Copyright 2009 Elsevier Ltd. All rights reserved. |
Affiliation:
|
Department of Internal Medicine and Gastroenterology, University of Bologna, Bologna, Italy. francesca.lodato@unibo.it |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Fractures, Bone
/
chemically induced Gastroenteritis / chemically induced, microbiology Humans Magnesium Deficiency / chemically induced Polyps / chemically induced Proton Pump Inhibitors / adverse effects* Risk Assessment Risk Factors Stomach Neoplasms / chemically induced Vitamin B 12 Deficiency / chemically induced |
| Chemical | |
Reg. No./Substance:
|
0/Proton Pump Inhibitors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Adverse effects of drugs in the treatment of viral hepatitis.
Next Document: Gastrointestinal and liver side effects of drugs in elderly patients.