Document Detail


Adverse effects of nutritional programming during prenatal and early postnatal life, some aspects of regulation and potential prevention and treatments.
MedLine Citation:
PMID:  19996479     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Nutritional programming, regulation and some ways for prevention/treatment to ameliorate or normalize adverse outcomes of programming are discussed. Epidemiological studies in human and animal experiments showed that nutrition during fetal and neonatal life may lead to related disorders in adulthood. But several argues may question its validity arising the question of the adequate models used to reproduce human situations. Protein level in milk formula intake by infant during neonatal life is discussed. Body weight at birth reflects the product growth trajectory during fetal life. Low birth weight is considered as the result of an adverse growth trajectory and is often associated with later metabolic diseases in adult age. But, the sum of prenatal growth trajectory, rapid growth in early infancy (catch up growth), early adiposity rebound in childhood must be considered to determine the origins of later diseases in adulthood. The review focuses the regulation of nutritional imprinting on hormonal and epigenetic mechanisms which are complementary. The HPA axis and GH-IGF axis may have a crucial role in the regulation induced by nutritional programming. The persistent alterations seem to be a consequence, at least in part, of elevated insulin levels during "critical periods" of pre- and early postnatal development. Also, leptin seems to play an important role in this complex system. New knowledge about these mechanisms involved suggest the development of new, rational, and effective preventive and/or therapeutic options before and/or after birth. Thus, early infancy may provide an opportunity for intervention aimed at reducing later disease risk.
Authors:
P Guilloteau; R Zabielski; H M Hammon; C C Metges
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of physiology and pharmacology : an official journal of the Polish Physiological Society     Volume:  60 Suppl 3     ISSN:  1899-1505     ISO Abbreviation:  J. Physiol. Pharmacol.     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-12-09     Completed Date:  2010-04-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9114501     Medline TA:  J Physiol Pharmacol     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  17-35     Citation Subset:  IM    
Affiliation:
INRA, U1079, Unite Mixte de Recherche - Systeme Elevage, Nutrition Animale et Humaine (UMR SENAH), Domaine de la Prise, 35590 Saint-Gilles, France. Paul.Guilloteau@rennes.inra.fr
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MeSH Terms
Descriptor/Qualifier:
Adult
Animals
Child Development
Child, Preschool
Chronic Disease
Epigenesis, Genetic
Female
Fetal Development / physiology*
Gene Expression Regulation, Developmental
Genomic Imprinting / physiology
Humans
Infant
Malnutrition / complications,  physiopathology*
Nutritional Physiological Phenomena
Nutritional Status*
Pregnancy
Prenatal Exposure Delayed Effects*
Prenatal Nutritional Physiological Phenomena*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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