Document Detail

Adverse effects of hydrosalpinx on pregnancy rates after in vitro fertilization-embryo transfer.
MedLine Citation:
PMID:  9757878     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine the effect of hydrosalpinx on the establishment of pregnancy after IVF-ET.
DESIGN: Metaanalysis.
SETTING: University medical center.
PATIENT(S) AND INTERVENTION(S): All published reports (n=13) and abstracts (n=10) in English that examined the relation between hydrosalpinx and IVF-ET were included in the analysis. The metaanalysis was performed by first calculating the odds ratios for each trial and then combining them to obtain a pooled estimate of the odds ratio and a 95% confidence interval.
MAIN OUTCOME MEASURE(S): Clinical pregnancy.
RESULT(S): A total of 5,569 cycles was reviewed in the group without hydrosalpinx, and a total of 1,144 was reviewed in the group with hydrosalpinx. The clinical pregnancy rate was approximately 50% lower in patients who had hydrosalpinx. Similarly, the implantation rate was decreased by 50%. These effects were observed also in thawed ET cycles. The abortion rate was more than twofold higher in patients who had hydrosalpinx.
CONCLUSION(S): This metaanalysis suggests that hydrosalpinx is associated with a reduced chance of implantation and an increased risk of pregnancy loss.
H B Zeyneloglu; A Arici; D L Olive
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Publication Detail:
Type:  Journal Article; Meta-Analysis    
Journal Detail:
Title:  Fertility and sterility     Volume:  70     ISSN:  0015-0282     ISO Abbreviation:  Fertil. Steril.     Publication Date:  1998 Sep 
Date Detail:
Created Date:  1998-10-09     Completed Date:  1998-10-09     Revised Date:  2014-11-13    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  492-9     Citation Subset:  IM    
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MeSH Terms
Embryo Transfer*
Exudates and Transudates
Fallopian Tube Diseases / complications*
Fertilization in Vitro*
Odds Ratio
Pregnancy Outcome
Pregnancy Rate*
Randomized Controlled Trials as Topic

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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