| Adverse effects of apraclonidine used in the diagnosis of Horner syndrome in infants. | |
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MedLine Citation:
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PMID: 17572343 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Apraclonidine, a selective alpha(2)-agonist, was developed to lower intraocular pressure and minimize the systemic side effects associated with the use of its parent drug, clonidine.(1) An investigation of the site of action of apraclonidine incidentally uncovered a reversal of anisocoria in patients with absent sympathetic innervation of one pupil (Horner syndrome) due to its alpha(1)-effect on a pupil with denervation supersensitivity.(2) It has been used as a diagnostic test for Horner syndrome.(3,4) We report adverse effects of topical apraclonidine when used in the diagnosis of Horner syndrome in infants. |
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Authors:
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Patrick Watts; Denise Satterfield; May Kim Lim |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus / American Association for Pediatric Ophthalmology and Strabismus Volume: 11 ISSN: 1091-8531 ISO Abbreviation: J AAPOS Publication Date: 2007 Jun |
Date Detail:
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Created Date: 2007-06-18 Completed Date: 2007-08-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9710011 Medline TA: J AAPOS Country: United States |
Other Details:
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Languages: eng Pagination: 282-3 Citation Subset: IM |
Affiliation:
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Department of Ophthalmology, University Hospital of Wales, Cardiff, United Kingdom. patrickowatts@yahoo.co.uk <patrickowatts@yahoo.co.uk> |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic alpha-Agonists
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adverse effects*,
diagnostic use Bradycardia / chemically induced* Clonidine / adverse effects, analogs & derivatives*, diagnostic use Emergency Treatment Female Horner Syndrome / diagnosis* Humans Infant Lethargy / chemically induced* Respiration Disorders / chemically induced* Sleep Disorders / chemically induced* |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic alpha-Agonists; 4205-90-7/Clonidine; 66711-21-5/apraclonidine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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