| Adverse effects of antitubercular drugs: epidemiology, mechanisms, and patient management | |
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MedLine Citation:
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PMID: 17336011 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Tuberculosis, what ever its localization, is an infectious disease which can be totally cured by combining antitubercular drugs. Current therapeutic regimens with isoniazid, rifampicin, pyrazinamide, ethambutol, and streptomycin have proved successful in treating tuberculosis. However, they are associated to a high rate of adverse effects that can lead to therapeutic failure. Understanding the nature and the severity of these adverse effects allows for their appropriate management. Toxic neuropathy and hepatitis are the most common adverse reactions to isoniazid. Rifampicin is generally well tolerated but some severe immuno-allergic reactions may occur in case of intermittent regimen. Pyrazinamide-induced liver injury is rare but sometimes lethal. Joint affections, usually due to hyperuricemia, are more frequent but easily manageable. The major adverse effect related to ethambutol is ocular optic neuropathy. It occurs dose-dependently and can be irreversible. Finally, administration of streptomycin is potentially associated with renal and cochleo-vestibular toxicity that might be milder than when induced by other aminoglycosides. The management of antituberculosis-induced adverse effects depends on parameters related to the adverse effect itself and to the administrated drug. |
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Authors:
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K Aouam; A Chaabane; C Loussaïef; F Ben Romdhane; N-A Boughattas; M Chakroun |
Publication Detail:
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Type: English Abstract; Journal Article; Review Date: 2007-03-01 |
Journal Detail:
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Title: Médecine et maladies infectieuses Volume: 37 ISSN: 0399-077X ISO Abbreviation: Med Mal Infect Publication Date: 2007 May |
Date Detail:
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Created Date: 2007-05-21 Completed Date: 2007-09-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0311416 Medline TA: Med Mal Infect Country: France |
Other Details:
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Languages: fre Pagination: 253-61 Citation Subset: IM |
Affiliation:
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Laboratoire de pharmacologie, faculté de médecine, 5019 Monastir, Tunisie. |
Vernacular Title:
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Les effets indésirables des antituberculeux: épidémiologie, mécanismes et conduite à tenir. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antitubercular Agents
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adverse effects* Humans Isoniazid / adverse effects Tuberculosis / drug therapy |
| Chemical | |
Reg. No./Substance:
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0/Antitubercular Agents; 54-85-3/Isoniazid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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