Document Detail

Adverse effects of antidepressants in the elderly.
MedLine Citation:
PMID:  1392225     Owner:  NLM     Status:  MEDLINE    
Depression is a common problem in old age and the use of antidepressant drugs is particularly prevalent among elderly patients. Limited data suggest that dose requirements may be lower in the elderly because of age-related changes in pharmacokinetics and perhaps also in sensitivity. The side effect profiles of the various antidepressants are reviewed with regard to their potential to cause specific problems in the older patients. Anticholinergic actions, orthostatic hypotension and sedative effects warrant particular care in the elderly.
L Nolan; K O'Malley
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Drugs & aging     Volume:  2     ISSN:  1170-229X     ISO Abbreviation:  Drugs Aging     Publication Date:    1992 Sep-Oct
Date Detail:
Created Date:  1992-11-18     Completed Date:  1992-11-18     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9102074     Medline TA:  Drugs Aging     Country:  NEW ZEALAND    
Other Details:
Languages:  eng     Pagination:  450-8     Citation Subset:  IM    
Department of Clinical Pharmacology, Royal College of Surgeons, Dublin, Ireland.
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MeSH Terms
Aging / metabolism
Antidepressive Agents / adverse effects*,  pharmacokinetics
Drug Interactions
Reg. No./Substance:
0/Antidepressive Agents

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