Document Detail


Adverse effects after radical external beam radiotherapy of localized prostatic adenocarcinoma using two-dimensional dose-planning and a limited field technique.
MedLine Citation:
PMID:  8695159     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Adverse effects were assessed after definitive limited field, 2-dimensional CT-planned radiation treatment of localized prostatic adenocarcinoma. In 66 surviving patients, out of a total of 176 treated patients, personal interviews were performed and self-administered questionnaires distributed. The average follow-up was 6.6 years. Adverse effects with regard to bowel function and micturition were investigated, and graded 0-4 with increasing severity and impact on performance status, essentially according to the RTOG toxicity scoring system. Sexual functions were registered on visual analogue scales. The majority of adverse effects were considered minor (grade 1) and did not require any treatment. Late adverse effects on bowel and bladder or urethra that required treatment (grade 2-4) were reported in up to 8% (n = 5) of cases respectively. Late bowel side-effects that interfered with life style (grade 3-4) occurred in up to 3% (n = 2) of patients; the majority were rectal complications. Corresponding urinary side-effects were registered in up to 6% (n = 4) of the patients. Major surgical interventions were not required. Sexual functions were substantially affected in 60% of cases not administered endocrine treatment. Multivariate analyses could not identify patient or treatment risk factors related to complications.
Authors:
G Ljung; M Häggman; H Hansson; L Holmberg; S Nilsson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta oncologica (Stockholm, Sweden)     Volume:  35     ISSN:  0284-186X     ISO Abbreviation:  Acta Oncol     Publication Date:  1996  
Date Detail:
Created Date:  1996-09-03     Completed Date:  1996-09-03     Revised Date:  2009-05-12    
Medline Journal Info:
Nlm Unique ID:  8709065     Medline TA:  Acta Oncol     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  445-50     Citation Subset:  IM    
Affiliation:
Department of Oncology, Akademiska sjukhuset, University Hospital, Uppsala, Sweden.
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MeSH Terms
Descriptor/Qualifier:
Adenocarcinoma / radiotherapy*
Aged
Aged, 80 and over
Follow-Up Studies
Humans
Interviews as Topic
Intestine, Large / radiation effects*
Life Style
Male
Middle Aged
Multivariate Analysis
Patient Care Planning
Prostatic Neoplasms / radiotherapy*
Questionnaires
Radiotherapy / adverse effects
Radiotherapy Dosage
Rectum / radiation effects
Risk Factors
Sex
Tomography, X-Ray Computed
Urethra / radiation effects
Urinary Bladder / radiation effects
Urinary Tract / radiation effects*
Urination / radiation effects

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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