| Adverse effects of acebutolol in chronic stable angina: drug-induced positive antinuclear antibody. | |
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MedLine Citation:
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PMID: 6209474 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Acebutolol, a cardioselective beta-adrenergic blocking agent, was administered for 48 weeks to 11 patients with chronic stable angina in a single-blind trial for determining efficacy and safety. As expected, beta-adrenergic blockade reduced angina frequency and improved exercise performance (p less than 0.001). Three patients developed an antinuclear antibody (ANA) titer, and in two patients a low titer present during placebo treatment increased fourfold. Two patients had joint symptoms probably related to acebutolol administration. Readministration of acebutolol after the ANA returned to negative resulted in a significant rise in ANA titer in two patients tested. The other nine patients tolerated long-term acebutolol therapy without significant side effects. |
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Authors:
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J N Bloomquist; A Laddu; R Engler |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of cardiovascular pharmacology Volume: 6 ISSN: 0160-2446 ISO Abbreviation: J. Cardiovasc. Pharmacol. Publication Date: 1984 Sep-Oct |
Date Detail:
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Created Date: 1984-12-28 Completed Date: 1984-12-28 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 7902492 Medline TA: J Cardiovasc Pharmacol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 735-8 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acebutolol
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adverse effects* Aged Angina Pectoris / drug therapy*, immunology Antibodies, Antinuclear / analysis* Autoimmune Diseases / chemically induced Chronic Disease Humans Lung / physiopathology Male Middle Aged Physical Exertion |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Antinuclear; 37517-30-9/Acebutolol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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