Document Detail

Adverse effects of acebutolol in chronic stable angina: drug-induced positive antinuclear antibody.
MedLine Citation:
PMID:  6209474     Owner:  NLM     Status:  MEDLINE    
Acebutolol, a cardioselective beta-adrenergic blocking agent, was administered for 48 weeks to 11 patients with chronic stable angina in a single-blind trial for determining efficacy and safety. As expected, beta-adrenergic blockade reduced angina frequency and improved exercise performance (p less than 0.001). Three patients developed an antinuclear antibody (ANA) titer, and in two patients a low titer present during placebo treatment increased fourfold. Two patients had joint symptoms probably related to acebutolol administration. Readministration of acebutolol after the ANA returned to negative resulted in a significant rise in ANA titer in two patients tested. The other nine patients tolerated long-term acebutolol therapy without significant side effects.
J N Bloomquist; A Laddu; R Engler
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of cardiovascular pharmacology     Volume:  6     ISSN:  0160-2446     ISO Abbreviation:  J. Cardiovasc. Pharmacol.     Publication Date:    1984 Sep-Oct
Date Detail:
Created Date:  1984-12-28     Completed Date:  1984-12-28     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7902492     Medline TA:  J Cardiovasc Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  735-8     Citation Subset:  IM    
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MeSH Terms
Acebutolol / adverse effects*
Angina Pectoris / drug therapy*,  immunology
Antibodies, Antinuclear / analysis*
Autoimmune Diseases / chemically induced
Chronic Disease
Lung / physiopathology
Middle Aged
Physical Exertion
Reg. No./Substance:
0/Antibodies, Antinuclear; 37517-30-9/Acebutolol

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