Document Detail


Adverse effect of chronic tonsillitis on clinical course of sarcoidosis.
MedLine Citation:
PMID:  1669976     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Sarcoidosis resolves spontaneously in many cases on a long-term basis. However, there are many cases whose resolution is delayed. We have experienced a frequent association of chronic tonsillitis (CTL), and dental caries in those patients of persistent course. We hypothesized that the presence of chronic or recurrent inflammatory foci in the upper airway may adversely affect the natural resolution of sarcoidosis. We analyzed the difference of regression of bilateral hilar lymphadenopathy on chest roentgenogram (CXR) in relation to changes in serum angiotensin converting enzyme (SACE) in sarcoidosis patients with and without CTL, and the effect of tonsillectomy (TLT) on the clinical course. In this study, we focused only on the tonsil for the sake of simplicity of analysis. Sarcoidosis resolved spontaneously in 10 of 28 (36%) patients with CTL and in 19 of 25 (76%) without CTL, and after TLT 9 cases became favorable in the course and the rate of unfavorable turned similar to those without CTL. The presence of CTL may be adversely related to the resolution of sarcoidosis.
Authors:
T Ikeda; N Daimaru; S Inutsuka; S Hayashi; N Shigematsu; T Nakashima; T Uemura
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Sarcoidosis     Volume:  8     ISSN:  0393-1447     ISO Abbreviation:  Sarcoidosis     Publication Date:  1991 Sep 
Date Detail:
Created Date:  1994-05-05     Completed Date:  1994-05-05     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8500778     Medline TA:  Sarcoidosis     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  120-4     Citation Subset:  IM    
Affiliation:
Research Institute for Diseases of the Chest, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Bacteria / isolation & purification
Child
Chronic Disease
Female
Humans
Male
Middle Aged
Peptidyl-Dipeptidase A / blood
Sarcoidosis, Pulmonary / complications*,  enzymology,  pathology
Tonsillectomy
Tonsillitis / complications*,  microbiology,  surgery
Chemical
Reg. No./Substance:
EC 3.4.15.1/Peptidyl-Dipeptidase A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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