| Adverse effect of the anabolic-androgenic steroid mesterolone on cardiac remodelling and lipoprotein profile is attenuated by aerobicz exercise training. | |
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MedLine Citation:
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PMID: 18808528 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Abuse of anabolic-androgenic steroids (AAS) for improving physical performance is associated with serious, sometimes fatal, adverse effects. The aim of the present work was to investigate the effects of AAS on the cardiac structure and the plasma lipoprotein profile isolated and in combination with exercise. Transgenic mice with a human lipaemic phenotype (expressing cholesteryl ester transfer protein on the LDL receptor knockout background) were used in this study. Sedentary and exercised mice (treadmill running, five times per week for 6 weeks) were treated with mesterolone (2 microg/g body weight) or vehicle (control-C) in the last 3 weeks. Four groups were compared: (i) exercise + mesterolone (Ex-M), (ii) exercise + vehicle (Ex-C), (iii) sedentary + mesterolone (Sed-M) and (iv) sedentary + vehicle (Sed-C). Arterial blood pressure and body mass increased in all groups along time, but Sed-M reached the highest values and Ex-C the lowest. Treatment with mesterolone increased total cholesterol, triglyceride, low-density lipoprotein cholesterol (LDL-c) and very LDL-c (VLDL-c) plasma levels. However, exercise blunted some of these deleterious effects by increasing high-density lipoprotein cholesterol and decreasing LDL-c, VLDL-c and triglycerides. Exercise training induced beneficial effects, such as physiological cardiomyocyte hypertrophy, increase in myocardial circulation and decrease in cardiac interstitium. However, mesterolone impaired such physiological gains and in addition increased troponin T plasma levels both in sedentary and exercised mice. Thus, while mesterolone induced pro-atherogenic lipoprotein profile and pathogenic cardiac hypertrophy, exercise counteracted these effects and modified favourably both the lipoprotein profile and the cardiac remodelling induced by mesterolone. |
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Authors:
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Karina Fontana; Helena Coutinho Franco Oliveira; Marta Beatriz Leonardo; Carlos Alberto Mandarim-de-Lacerda; Maria Alice da Cruz-Höfling |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: International journal of experimental pathology Volume: 89 ISSN: 1365-2613 ISO Abbreviation: Int J Exp Pathol Publication Date: 2008 Oct |
Date Detail:
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Created Date: 2008-09-23 Completed Date: 2008-12-04 Revised Date: 2011-12-21 |
Medline Journal Info:
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Nlm Unique ID: 9014042 Medline TA: Int J Exp Pathol Country: England |
Other Details:
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Languages: eng Pagination: 358-66 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas (UNICAMP), Campinas, SP, Brazil. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anabolic Agents
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adverse effects* Animals Cholesterol Ester Transfer Proteins / genetics Exercise / physiology* Humans Hypertrophy, Left Ventricular / blood, pathology*, therapy Lipoproteins / blood* Male Mesterolone / adverse effects* Mice Mice, Knockout Mice, Transgenic Myocardium / pathology* Receptors, LDL / genetics Troponin T / blood |
| Chemical | |
Reg. No./Substance:
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0/Anabolic Agents; 0/Cholesterol Ester Transfer Proteins; 0/Lipoproteins; 0/Receptors, LDL; 0/Troponin T; 1424-00-6/Mesterolone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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