Document Detail

Adverse drug reactions to anthelmintics.
MedLine Citation:
PMID:  14749518     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Anthelmintics are commonly used in tropical areas, but are also prescribed in Western countries with other climates. However, pharmacoepidemiologic studies of these drugs are rare. OBJECTIVE: To investigate adverse drug reactions (ADRs) due to anthelmintics. METHODS: All spontaneous reports of ADRs associated with albendazole, diethylcarbamazine, flubendazole, ivermectin, mebendazole, niclosamide, praziquantel, pyrantel pamoate, and thiabendazole were identified in the French Pharmacovigilance Database from January 1, 1985, to August 31, 1999. For each case, the following data were recorded: age, gender, weight, ADRs, drug, dosage, and indication. RESULTS: A total of 243 cases were found corresponding to 291 ADRs. Serious ADRs (hematologic or hepatic injury) to albendazole most often occurred when the drug was used for the treatment of echinococcosis or cysticercosis, thus requiring both high dosage and long duration of therapy. Our data show that the profile and seriousness of anthelmintic-induced ADRs vary according to their use. Furthermore, the low number of spontaneous reporting of ADRs suggests a high rate of underreporting for these drugs, which are often considered in France as orphan drugs. CONCLUSIONS: The improvement of reporting of serious or unrecognized (unlabeled) anthelmintic-induced ADRs will increase our knowledge of the benefit/risk ratio associated with these agents and optimize their use.
Haleh Bagheri; Elise Simiand; Jean-Louis Montastruc; Jean-François Magnaval
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Publication Detail:
Type:  Journal Article     Date:  2004-01-23
Journal Detail:
Title:  The Annals of pharmacotherapy     Volume:  38     ISSN:  1060-0280     ISO Abbreviation:  Ann Pharmacother     Publication Date:  2004 Mar 
Date Detail:
Created Date:  2004-02-18     Completed Date:  2004-05-25     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9203131     Medline TA:  Ann Pharmacother     Country:  United States    
Other Details:
Languages:  eng     Pagination:  383-8     Citation Subset:  IM    
Department of Pharmacology, Midi-Pyrenees Center of Pharmacovigilance, Faculty of Medicine, Toulouse University Hospital, Toulouse, France.
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MeSH Terms
Adverse Drug Reaction Reporting Systems / statistics & numerical data*
Anthelmintics / adverse effects*
Middle Aged
United States
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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