| Adverse drug reactions resulting in hyperthermia in the intensive care unit. | |
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MedLine Citation:
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PMID: 20502177 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hyperthermia is frequently seen in the intensive care setting and is associated with significant morbidity and mortality. It is often initially misdiagnosed as fever associated with infection. Atypical presentations of classic syndromes are common. Clinical suspicion is the key to diagnosis. Adverse drug reactions are a frequent culprit. Syndromes include adrenergic "fever," anticholinergic "fever," antidopaminergic "fever," serotonin syndrome, malignant hyperthermia, uncoupling of oxidative phosphorylation, and withdrawal from baclofen. This review describes the pathophysiology of hyperthermia, as distinct from fever, and the physiology, diagnosis, and treatment of serotonin syndrome, neuroleptic malignant syndrome, malignant hyperthermia, and baclofen withdrawal. Much of the available evidence regarding the treatment of these disorders is based on single case reports, case series, or animal models. Therapeutic modalities consist of identification/withdrawal of possible offending agent(s), support directed at lowering temperature and preventing/treating complications, as well as targeted pharmacologic therapy directed at the specific cause. Early recognition and treatment using a multidisciplinary approach are essential to achieve the best possible outcome. |
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Authors:
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Karen J McAllen; David R Schwartz |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Critical care medicine Volume: 38 ISSN: 1530-0293 ISO Abbreviation: Crit. Care Med. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-26 Completed Date: 2010-07-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0355501 Medline TA: Crit Care Med Country: United States |
Other Details:
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Languages: eng Pagination: S244-52 Citation Subset: AIM; IM |
Affiliation:
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Department of Pharmacy, Spectrum Health Hospitals, Grand Rapids, MI, USA. karen.mcallen@spectrum-health.org |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Baclofen
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adverse effects Drug Toxicity / complications*, diagnosis, physiopathology, therapy Fever / chemically induced*, diagnosis, physiopathology, therapy Humans Intensive Care / methods Intensive Care Units* Malignant Hyperthermia / diagnosis, physiopathology, therapy Neuroleptic Malignant Syndrome / diagnosis, physiopathology, therapy Serotonin Syndrome / diagnosis, physiopathology, therapy Substance Withdrawal Syndrome / diagnosis, physiopathology, therapy United States |
| Chemical | |
Reg. No./Substance:
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1134-47-0/Baclofen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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