| Adverse drug reactions in newborns, infants and toddlers: pediatric pharmacovigilance between present and future. | |
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MedLine Citation:
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PMID: 21548838 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The detection, assessment, understanding and prevention of adverse drug reactions (ADRs) are the primary aims of pharmacovigilance activities. Pediatric patients, especially all newborns and infants, are particularly at risk for experiencing drug-related adverse events. AREAS COVERED: This review briefly analyzes the physiological peculiarities of pharmacodynamic and pharmacokinetic aspects of drugs in newborns, infants and toddlers and children. It also deals with specific pediatric pharmacovigilance aspects, such as the frequent use of unlicensed and/or off-label drugs in neonatal intensive care units in European countries and in Australia. This review reports on European, American and Canadian data about the incidence and type of pediatric ADRs, particularly focusing on neonates, infants and toddlers. EXPERT OPINION: The awareness of pediatricians about the importance of reporting ADRs should be stimulated, new reporting systems should be encouraged and pediatric pharmacovigilance activities should be improved, first, by intensifying active post-marketing surveillance methods. |
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Authors:
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Valentina Fabiano; Chiara Mameli; Gian Vincenzo Zuccotti |
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Publication Detail:
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Type: Journal Article; Review Date: 2011-05-09 |
Journal Detail:
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Title: Expert opinion on drug safety Volume: 11 ISSN: 1744-764X ISO Abbreviation: Expert Opin Drug Saf Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2011-12-26 Completed Date: 2012-04-20 Revised Date: 2013-05-20 |
Medline Journal Info:
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Nlm Unique ID: 101163027 Medline TA: Expert Opin Drug Saf Country: England |
Other Details:
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Languages: eng Pagination: 95-105 Citation Subset: IM |
Affiliation:
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Luigi Sacco Hospital, Department of Pediatrics, Università degli Studi di Milano, Via GB Grassi, 74, 20157, Milan, Italy. fabiano.valentina@hsacco.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adverse Drug Reaction Reporting Systems* Age Factors Child, Preschool Humans Incidence Infant Infant, Newborn Off-Label Use Pharmaceutical Preparations / administration & dosage, adverse effects* Pharmacovigilance* |
| Chemical | |
Reg. No./Substance:
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0/Pharmaceutical Preparations |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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