Document Detail

Adverse birth outcomes in United Republic of Tanzania--impact and prevention of maternal risk factors.
MedLine Citation:
PMID:  17242753     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine risk factors for poor birth outcome and their population attributable fractions.
METHODS: 1688 women who attended for antenatal care were recruited into a prospective study of the effectiveness of syphilis screening and treatment. All women were screened and treated for syphilis and other reproductive tract infections (RTIs) during pregnancy and followed to delivery to measure the incidence of stillbirth, intrauterine growth retardation (IUGR), low birth weight (LBW) and preterm live birth.
FINDINGS: At delivery, 2.7% of 1536 women experienced a stillbirth, 12% of live births were preterm and 8% were LBW. Stillbirth was independently associated with a past history of stillbirth, short maternal stature and anaemia. LBW was associated with short maternal stature, ethnicity, occupation, gravidity and maternal malaria whereas preterm birth was associated with occupation, age of sexual debut, untreated bacterial vaginosis and maternal malaria. IUGR was associated with gravidity, maternal malaria, short stature, and delivering a female infant. In the women who had been screened and treated for syphilis, in between 20 and 34% of women with each outcome was estimated to be attributable to malaria, and 63% of stillbirths were estimated as being attributable to maternal anaemia. Screening and treatment of RTIs was effective and no association was seen between treated RTIs and adverse pregnancy outcomes.
CONCLUSION: Maternal malaria and anaemia continue to be significant causes of adverse pregnancy outcome in sub-Saharan Africa. Providing reproductive health services that include treatment of RTIs and prevention of malaria and maternal anaemia to reduce adverse birth outcomes remains a priority.
Deborah Watson-Jones; Helen A Weiss; John M Changalucha; James Todd; Balthazar Gumodoka; Judith Bulmer; Rebecca Balira; David Ross; Kokungoza Mugeye; Richard Hayes; David Mabey
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Bulletin of the World Health Organization     Volume:  85     ISSN:  0042-9686     ISO Abbreviation:  Bull. World Health Organ.     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2007-01-23     Completed Date:  2007-02-16     Revised Date:  2014-02-19    
Medline Journal Info:
Nlm Unique ID:  7507052     Medline TA:  Bull World Health Organ     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  9-18     Citation Subset:  IM    
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MeSH Terms
Genital Diseases, Female / complications,  epidemiology
Infant, Low Birth Weight
Infant, Newborn
Mass Screening
Maternal Health Services*
Pregnancy Outcome / epidemiology*
Premature Birth / epidemiology
Prospective Studies
Risk Factors
Socioeconomic Factors
Stillbirth / epidemiology
Syphilis / complications,  diagnosis*,  epidemiology*
Tanzania / epidemiology
Grant Support
G0501954//Medical Research Council; //Wellcome Trust

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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