| Adverse birth outcome among mothers with low serum cholesterol. | |
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MedLine Citation:
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PMID: 17908758 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The objective of this study was to assess whether low maternal serum cholesterol during pregnancy is associated with preterm delivery, impaired fetal growth, or congenital anomalies in women without identified major risk factors for adverse pregnancy outcome. METHODS: Mother-infant pairs were retrospectively ascertained from among a cohort of 9938 women who were referred to South Carolina prenatal clinics for routine second-trimester serum screening. Banked sera were assayed for total cholesterol; <10th percentile of assayed values (159 mg/dL at mean gestational age of 17.6 weeks) defined a "low total cholesterol" prenatal risk category. Eligible women were aged 21 to 34 years and nonsmoking and did not have diabetes; neonates were liveborn after singleton gestations. Total cholesterol values of eligible mothers were adjusted for gestational age at screening before risk group assignment. The study population included 118 women with low total cholesterol and 940 women with higher total cholesterol. Primary analyses used multivariate regression models to compare rates of preterm delivery, fetal growth parameters, and congenital anomalies between women with low total cholesterol and control subjects with mid-total cholesterol values >10th percentile but <90th percentile. RESULTS: Prevalence of preterm delivery among mothers with low total cholesterol was 12.7%, compared with 5.0% among control subjects with mid-total cholesterol. The association of low maternal serum cholesterol with preterm birth was observed only among white mothers. Term infants of mothers with low total cholesterol weighed on average 150 g less than those who were born to control mothers. A trend of increased microcephaly risk among neonates of mothers with low total cholesterol was found. Low maternal serum cholesterol was unassociated with risk for congenital anomalies. CONCLUSIONS: Total serum cholesterol <10th population percentile was strongly associated with preterm delivery among otherwise low-risk white mothers in this pilot study population. Term infants of mothers with low total cholesterol weighed less than control infants among both racial groups. |
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Authors:
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Robin J Edison; Kate Berg; Alan Remaley; Richard Kelley; Charles Rotimi; Roger E Stevenson; Maximilian Muenke |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Intramural |
Journal Detail:
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Title: Pediatrics Volume: 120 ISSN: 1098-4275 ISO Abbreviation: Pediatrics Publication Date: 2007 Oct |
Date Detail:
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Created Date: 2007-10-02 Completed Date: 2007-10-29 Revised Date: 2007-12-07 |
Medline Journal Info:
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Nlm Unique ID: 0376422 Medline TA: Pediatrics Country: United States |
Other Details:
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Languages: eng Pagination: 723-33 Citation Subset: AIM; IM |
Affiliation:
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Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Department of Health and Human Services, 35 Convent Dr, Bethesda, MD 20892-3717, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Birth Weight Case-Control Studies Cholesterol / blood* Continental Population Groups Female Humans Infant, Newborn Linear Models Microcephaly / epidemiology Pilot Projects Pregnancy Pregnancy Outcome* Premature Birth / epidemiology Retrospective Studies |
| Chemical | |
Reg. No./Substance:
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57-88-5/Cholesterol |
| Comments/Corrections | |
Comment In:
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Pediatrics. 2007 Nov;120(5):1133-4
[PMID:
17974752
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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