Document Detail

Adverse reactions following immunization with MMR vaccine in children at selected provinces of Iran.
MedLine Citation:
PMID:  21361714     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Several adverse events following immunization (AEFI) have been attributed to immunization with live attenuated measles, mumps, and rubella (MMR) vaccines. The MMR vaccine was introduced into the routine infant immunization schedule in 2003, followed by a second dose of vaccine at school-entry for children 4 to 6 years of age. The objective of this study was to characterize adverse reactions following MMR vaccination in Iran.
METHODS: Children who received the MMR vaccine and resided in five selected provinces of Iran were examined weekly for four weeks to detect well-known AEFIs that included: parotitis, fever and convulsions, convulsions without fever, encephalopathy, and anaphylactic reactions. Incidence of AEFIs were calculated and compared among recipients in both age groups.
RESULTS: During the follow-up period, trained providers reported 792 AEFIs. Parotitis was the most frequent event occurring in 1.8% of recipients. Of 14,109 children vaccinated at 12 months of age the following AEFIs occurred: parotitis (147), fever and convulsions (8), convulsions (7), encephalopathy (1), and anaphylactic reactions (1). Of 29,338 children vaccinated at 4 to 6 years of age, parotitis, fever and convulsions, encephalopathy, and anaphylaxis occurred in 626, 5, 1, and 1 child, respectively; no convulsions without fever were reported in this age group.
CONCLUSION: Parotitis is the most frequent AEFI among MMR vaccine recipients in Iran. Incidence rates of AEFIs following MMR vaccination in Iran are similar to rates of AEFIs reported in other studies.
Abdoulreza Esteghamati; Abbasali Keshtkar; Ramin Heshmat; Mohammad Mehdi Gouya; Masoud Salar Amoli; Shahnaz Armin; Frank Mahoney
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of Iranian medicine     Volume:  14     ISSN:  1735-3947     ISO Abbreviation:  Arch Iran Med     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-03-02     Completed Date:  2011-07-22     Revised Date:  2013-05-15    
Medline Journal Info:
Nlm Unique ID:  100889644     Medline TA:  Arch Iran Med     Country:  Iran    
Other Details:
Languages:  eng     Pagination:  91-5     Citation Subset:  IM    
Department of Pediatrics, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
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MeSH Terms
Anaphylaxis / chemically induced,  epidemiology
Child, Preschool
Fever / chemically induced,  epidemiology
Immunization Programs*
Iran / epidemiology
Measles-Mumps-Rubella Vaccine / administration & dosage,  adverse effects*
Parotitis / chemically induced,  epidemiology
Seizures / chemically induced,  epidemiology
Vaccines, Combined
Reg. No./Substance:
0/Measles-Mumps-Rubella Vaccine; 0/Vaccines, Combined

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