| Adverse and protective influences of adenosine on the newborn and embryo: implications for preterm white matter injury and embryo protection. | |
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MedLine Citation:
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PMID: 21228731 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Few signaling molecules have the potential to influence the developing mammal as the nucleoside adenosine. Adenosine levels increase rapidly with tissue hypoxia and inflammation. Adenosine antagonists include the methylxanthines caffeine and theophylline. The receptors that transduce adenosine action are the A1, A2a, A2b, and A3 adenosine receptors (ARs). In the postnatal period, A1AR activation may contribute to white matter injury in the preterm infant by altering oligodendrocyte (OL) development. In models of perinatal brain injury, caffeine is neuroprotective against periventricular white matter injury (PWMI) and hypoxic-ischemic encephalopathy (HIE). Supporting the notion that blockade of adenosine action is of benefit in the premature infant, caffeine reduces the incidence of bronchopulmonary dysplasia and CP in clinical studies. In comparison with the adverse effects on the postnatal brain, adenosine acts via A1ARs to play an essential role in protecting the embryo from hypoxia. Embryo protective effects are blocked by caffeine, and caffeine intake during early pregnancy increases the risk of miscarriage and fetal growth retardation. Adenosine and adenosine antagonists play important modulatory roles during mammalian development. The protective and deleterious effects of adenosine depend on the time of exposure and target sites of action. |
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Authors:
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Scott A Rivkees; Christopher C Wendler |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review |
Journal Detail:
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Title: Pediatric research Volume: 69 ISSN: 1530-0447 ISO Abbreviation: Pediatr. Res. Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-03-04 Completed Date: 2011-06-13 Revised Date: 2013-05-27 |
Medline Journal Info:
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Nlm Unique ID: 0100714 Medline TA: Pediatr Res Country: United States |
Other Details:
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Languages: eng Pagination: 271-8 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Yale Child Health Research Center, Yale University School of Medicine, New Haven, Connecticut 06520, USA. scott.rivkees@yale.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine
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antagonists & inhibitors,
pharmacology*,
therapeutic use Animals Caffeine / pharmacology Embryo, Mammalian / drug effects*, physiology Female Humans Hypoxia-Ischemia, Brain / drug therapy Infant, Newborn Infant, Premature Leukomalacia, Periventricular / drug therapy Nerve Fibers, Myelinated / drug effects*, pathology* Neuroprotective Agents / pharmacology*, therapeutic use Oligodendroglia / drug effects, pathology Pregnancy Protein Isoforms / genetics, metabolism Purinergic P1 Receptor Antagonists / pharmacology Receptors, Purinergic P1 / genetics, metabolism Respiration / drug effects |
| Grant Support | |
ID/Acronym/Agency:
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1R01HD056281/HD/NICHD NIH HHS; 1R01NS068039/NS/NINDS NIH HHS; R01 HD058086-01A2/HD/NICHD NIH HHS; R01 NS068039-01A1/NS/NINDS NIH HHS; R21NS051191/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Neuroprotective Agents; 0/Protein Isoforms; 0/Purinergic P1 Receptor Antagonists; 0/Receptors, Purinergic P1; 58-08-2/Caffeine; 58-61-7/Adenosine |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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