| Adverse Prognostic Impact of Abnormal Lesions Detected by Genome-Wide Single Nucleotide Polymorphism Array-Based Karyotyping Analysis in Acute Myeloid Leukemia With Normal Karyotype. | |
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MedLine Citation:
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PMID: 22084373 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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PURPOSEThis study attempted to analyze the prognostic role of single nucleotide polymorphism array (SNP-A) -based karyotying in 133 patients with acute myeloid leukemia with normal karyotype (AML-NK), which presents with diverse clinical outcomes, thus requiring further stratification of patient subgroups according to their prognoses. PATIENTS AND METHODSA total of 133 patients with AML-NK confirmed by metaphase cytogenetics (MC) and fluorescent in situ hybridization analysis were included in this study. Analysis by Genome-Wide Human SNP 6.0 Array was performed by using DNAs derived from marrow samples at diagnosis.ResultsForty-three patients (32.3%) had at least one abnormal SNP lesion that was not detected by MC. One hundred thirteen abnormal SNP lesions included 55 losses, 23 gains, and 35 copy-neutral losses of heterozygosity. Multivariate analyses showed that detection of abnormal SNP lesions by SNP-A karyotyping results in an unfavorable prognostic value for overall survival (hazard ratio [HR], 2.69; 95% CI, 1.50 to 4.82; P = .001); other significant prognostic factors included secondary AML (HR, 5.55; 95% CI, 1.80 to 17.14; P = .003), presence of the FLT3 mutation (HR, 3.17; 95% CI, 1.71 to 5.87; P < .001), and age (HR, 1.03; 95% CI, 1.01 to 1.05; P = .020). CONCLUSIONOur data demonstrated that abnormal SNP lesions detected by SNP-A karyotyping might indicate an adverse prognosis in patients with AML-NK, thus requiring a more sophisticated treatment strategy for improvement of treatment outcomes. |
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Authors:
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Jun Ho Yi; Jungwon Huh; Hee-Jin Kim; Sun-Hee Kim; Hyeoung-Joon Kim; Yeo-Kyeoung Kim; Sang Kyun Sohn; Joon Ho Moon; Sung Hyun Kim; Kyoung Ha Kim; Jong Ho Won; Yeung Chul Mun; Hawk Kim; Jinny Park; Chul Won Jung; Dong Hwan Kim |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-11-14 |
Journal Detail:
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Title: Journal of clinical oncology : official journal of the American Society of Clinical Oncology Volume: - ISSN: 1527-7755 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8309333 Medline TA: J Clin Oncol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Jun Ho Yi, Hee-Jin Kim, Sun-Hee Kim, Chul Won Jung, and Dong Hwan Kim, Sungkyunkwan University School of Medicine; Jungwon Huh and Yeung Chul Mun, Ewha Womans University School of Medicine; Kyoung Ha Kim and Jong Ho Won, Soonchunhyang University Seoul Hospital; Jun Ho Yi, Yonsei University College of Medicine, Seoul; Hyeoung-Joon Kim and Yeo-Kyeoung Kim, Chonnam National University, Hwasun; Sang Kyun Sohn and Joon Ho Moon, Kyungpook National University, Daegu; Sung Hyun Kim, DongA University, Busan; Hawk Kim, University of Ulsan College of Medicine, Ulsan; Jinny Park, Gachon University Gil Hospital, Incheon, Korea; and Dong Hwan Kim, University of Toronto, Toronto, Ontario, Canada. |
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