| Adverse impact of mood on flow-mediated dilation. | |
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MedLine Citation:
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PMID: 20100885 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To examine the impact of mood states on endothelial function, as measured noninvasively by brachial artery flow-mediated dilation (FMD). Substantial literature indicates that negative mood is linked to cardiovascular disease (CVD). However, the mechanisms underlying this relationship are not well defined. CVD is often preceded by dysfunction of the endothelium. METHODS: Healthy adults (n = 70; mean age, 36 years) completed the Profile of Mood States (POMS), which contains six subscales (depression/dejection; tension/anxiety; anger/hostility; confusion/bewilderment; fatigue/inertia; vigor/activity) that are used to compute a total mood disturbance score for overall psychological distress. FMD was calculated (maximum percentage change in brachial artery diameter) from ultrasound assessment of arterial diameter at baseline and for 10 minutes after occlusion. RESULTS: Regressions showed that increases in POMS total mood disturbance scores were associated with decreases in endothelial function. Mood disturbance explained 10% of the variance in FMD (p < .01), after controlling for age, sex, mean arterial pressure, body mass index, and socially desirable response bias. An exploratory set of separate regressions conducted to decompose the link between FMD and total mood disturbance revealed that the following POMS subscales were inversely correlated with FMD: depression/dejection, tension/anxiety, anger/hostility, fatigue/inertia (p's < .05), and confusion/bewilderment (p < .01). CONCLUSIONS: Mood disturbance could contribute to CVD via impaired vasodilation. These preliminary results show that even mild levels of adverse psychological states, particularly depressed, anxious, angry, confused, and fatigued states, might be linked to increased cardiovascular risk. |
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Authors:
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Denise C Cooper; Milos S Milic; Joseph R Tafur; Paul J Mills; Wayne A Bardwell; Michael G Ziegler; Joel E Dimsdale |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural Date: 2010-01-25 |
Journal Detail:
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Title: Psychosomatic medicine Volume: 72 ISSN: 1534-7796 ISO Abbreviation: Psychosom Med Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-02-10 Completed Date: 2010-03-15 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 0376505 Medline TA: Psychosom Med Country: United States |
Other Details:
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Languages: eng Pagination: 122-7 Citation Subset: IM |
Affiliation:
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Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093-0804, USA. dccooper@ucsd.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anxiety / physiopathology Atherosclerosis / etiology, physiopathology Brachial Artery / physiopathology* Cardiovascular Diseases / etiology, physiopathology Confusion / physiopathology Depression / physiopathology Dilatation, Pathologic / physiopathology* Endothelium, Vascular / physiopathology* Fatigue / physiopathology Female Humans Male Middle Aged Mood Disorders / physiopathology* Risk Factors Stress, Psychological / physiopathology* Vasodilation / physiology |
| Grant Support | |
ID/Acronym/Agency:
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HL36005/HL/NHLBI NIH HHS; P60MD00220/MD/NCMHD NIH HHS; R01 HL036005-24/HL/NHLBI NIH HHS; R01 HL036005-24S1/HL/NHLBI NIH HHS; RR00827/RR/NCRR NIH HHS |
| Comments/Corrections | |
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