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Adventitial fibroblasts from apoE(-/-) mice exhibit the characteristics of transdifferentiation into myofibroblasts.
MedLine Citation:
PMID:  23339104     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Adventitial fibroblasts (AFs) are the main cell type in the adventitia, however, their role in atherosclerosis remains unclear. We have investigate the role of AFs in atherosclerotic lesion formation by comparing the characteristics of AFs from apoE(-/-) to C57BL/6 mice. A minority of AFs from apoE(-/-) mice expressed α-SM-actin, but no α-SM-actin-positive cells were found in AFs from C57BL/6 mice. The content of total collagens, and the mRNA levels of collagen I and collagen III in AFs of apoE(-/-) mice, were higher than in C57BL/6 mice. AFs from apoE(-/-) mice proliferate and migrate faster, and synthesized more TGF-β(1) , MCP-1, and PDGF-b AFs from apoE(-/-) mice have the characteristics of transdifferentiation into myofibroblasts, including enhanced proliferation and migration, along with synthesis of collagens and cytokines compared to AFs from C57BL/6 mice. The histological and functional characteristics of AFs may contribute to early atherosclerotic lesion formation.
Authors:
Fang Xu; Ying Liu; Weicheng Hu
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cell biology international     Volume:  37     ISSN:  1095-8355     ISO Abbreviation:  Cell Biol. Int.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9307129     Medline TA:  Cell Biol Int     Country:  England    
Other Details:
Languages:  eng     Pagination:  160-6     Citation Subset:  IM    
Copyright Information:
© 2013 International Federation for Cell Biology.
Affiliation:
Department of Pathophysiology, Binzhou Medical University, 346 Guanhai Road, Yantai 264003, China.
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