| Advantages of peptide nucleic acids as diagnostic platforms for detection of nucleic acids in resource-limited settings. | |
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MedLine Citation:
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PMID: 20225945 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Peptide nucleic acids are a class of nondegradable oligonucleotide mimics that can be used as probes for nucleic acid sequences and could convey the necessary stability to be a diagnostic tool for use in a resource-limited setting. In this review, there is a brief introduction to the field of peptide nucleic acids and their potential benefits as probes for DNA and RNA sequences, followed by highlights of ways by which peptide nucleic acids could benefit a number of established diagnostic tools for human immunodeficiency virus detection. |
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Authors:
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Ning Zhang; Daniel H Appella |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Intramural; Review |
Journal Detail:
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Title: The Journal of infectious diseases Volume: 201 Suppl 1 ISSN: 1537-6613 ISO Abbreviation: J. Infect. Dis. Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-03-15 Completed Date: 2010-04-19 Revised Date: 2011-07-28 |
Medline Journal Info:
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Nlm Unique ID: 0413675 Medline TA: J Infect Dis Country: United States |
Other Details:
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Languages: eng Pagination: S42-5 Citation Subset: AIM; IM |
Affiliation:
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Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Communicable Diseases
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diagnosis* DNA / genetics, isolation & purification* Developing Countries Humans Microbiological Techniques / methods* Molecular Probe Techniques* Peptide Nucleic Acids / diagnostic use* RNA / genetics, isolation & purification* |
| Grant Support | |
ID/Acronym/Agency:
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Z01 DK031119-03/DK/NIDDK NIH HHS; Z01 DK031143-04/DK/NIDDK NIH HHS; ZIA DK031143-05/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Peptide Nucleic Acids; 63231-63-0/RNA; 9007-49-2/DNA |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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