Document Detail


Advantages of paramagnetic chemical exchange saturation transfer (CEST) complexes having slow to intermediate water exchange properties as responsive MRI agents.
MedLine Citation:
PMID:  23055299     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Paramagnetic chemical exchange saturation transfer (PARACEST) complexes are exogenous contrast agents that have great potential to further extend the functional and molecular imaging capabilities of magnetic resonance. As a result of the presence of a central paramagnetic lanthanide ion (Ln(3+) ≠ La(3+) , Gd(3+) , Lu(3+) ) within the chelate, the resonance frequencies of exchangeable protons bound to the PARACEST agent are shifted far away from the bulk water frequency. This large chemical shift, combined with an extreme sensitivity to the chemical exchange rate, make PARACEST agents ideally suited for the reporting of significant biological metrics, such as temperature, pH and the presence of metabolites. In addition, the ability to turn PARACEST agents 'off' and 'on' using a frequency-selective saturation pulse gives them a distinct advantage over Gd(3+) -based contrast agents. A current challenge for PARACEST research is the translation of the promising in vitro results into in vivo systems. This short review article first describes the basic theory behind PARACEST contrast agents, their benefits over other contrast agents and their applications to MRI. It then describes some of the recent PARACEST research results: specifically, pH measurements using water molecule exchange rate modulation, T2 exchange contrast caused by water molecule exchange, the use of ultrashort TEs (TE < 10 µs) to overcome T2 exchange line broadening and the potential application of T2 exchange as a new contrast mechanism for MRI.
Authors:
Todd C Soesbe; Yunkou Wu; A Dean Sherry
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2012-10-11
Journal Detail:
Title:  NMR in biomedicine     Volume:  26     ISSN:  1099-1492     ISO Abbreviation:  NMR Biomed     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-06-20     Completed Date:  2014-01-13     Revised Date:  2014-07-02    
Medline Journal Info:
Nlm Unique ID:  8915233     Medline TA:  NMR Biomed     Country:  England    
Other Details:
Languages:  eng     Pagination:  829-38     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 John Wiley & Sons, Ltd.
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MeSH Terms
Descriptor/Qualifier:
Animals
Chemical Phenomena*
Contrast Media / diagnostic use*
Humans
Magnetic Phenomena*
Magnetic Resonance Imaging*
Water / chemistry*
Grant Support
ID/Acronym/Agency:
1P30 CA142543/CA/NCI NIH HHS; CA-115531/CA/NCI NIH HHS; CA-126608/CA/NCI NIH HHS; EB-004582/EB/NIBIB NIH HHS; P30 CA142543/CA/NCI NIH HHS; P41 EB015908/EB/NIBIB NIH HHS; R01 CA115531/CA/NCI NIH HHS; R01 EB004582/EB/NIBIB NIH HHS; R13 EB015773/EB/NIBIB NIH HHS; RR-02584/RR/NCRR NIH HHS; U24 CA126608/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Contrast Media; 059QF0KO0R/Water
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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