| Advantages of an increased dose of MRI contrast agent for enhancing inflammatory synovium. | |
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MedLine Citation:
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PMID: 8689824 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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MRI intravenous contrast enhancement of inflammatory synovium has been studied at two different doses to determine to what extent enhancement is dose dependent. 19 patients with clinically active rheumatoid arthritis involving a knee were scanned twice, one week apart, using 0.1 mmol/kg of gadoteridol (ProHance) on the first occasion and 0.3 mmol/kg on the second. Static pre-and post-contrast images together with dynamic images immediately following injection were obtained on a 1.0T scanner. On subjective assessment, 84% of patients showed improved enhancement. 47% showed more enhancing tissue, a clearer delineation of enhancing tissue or both. Objectively, enhancement was increased significantly at the higher dose, as judged by the percentage increase in mean signal intensity within regions of interest plotted over the suprapatellar pouch (1723% v. 1005% enhancement P < 0.05). In practical terms the better visualization of enhancing tissue achieved with higher doses is likely to reduce margins of error in attempts at quantification from MRI scans, particularly of synovial volume, but emphasizes also the need for care and consistency to be exercised in calculating the exact dose of contrast medium to be administered. |
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Authors:
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C Oliver; S Speake; I Watt; P Dieppe; G Ratcliffe |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical radiology Volume: 51 ISSN: 0009-9260 ISO Abbreviation: Clin Radiol Publication Date: 1996 Jul |
Date Detail:
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Created Date: 1996-08-23 Completed Date: 1996-08-23 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 1306016 Medline TA: Clin Radiol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 487-93 Citation Subset: IM |
Affiliation:
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Department of Radiology, Bristol Royal Infirmary, Lugano, Switzerland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Arthritis, Rheumatoid / complications, pathology Contrast Media* Female Humans Image Enhancement* Knee Joint Magnetic Resonance Imaging* Male Middle Aged Sensitivity and Specificity Synovial Membrane / pathology* Synovitis / diagnosis*, etiology |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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