| Advances in urinary proteome analysis and biomarker discovery. | |
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MedLine Citation:
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PMID: 17329573 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Noninvasive diagnosis of kidney diseases and assessment of the prognosis are still challenges in clinical nephrology. Definition of biomarkers on the basis of proteome analysis, especially of the urine, has advanced recently and may provide new tools to solve those challenges. This article highlights the most promising technological approaches toward deciphering the human proteome and applications of the knowledge in clinical nephrology, with emphasis on the urinary proteome. The data in the current literature indicate that although a thorough investigation of the entire urinary proteome is still a distant goal, clinical applications are already available. Progress in the analysis of human proteome in health and disease will depend more on the standardization of data and availability of suitable bioinformatics and software solutions than on new technological advances. It is predicted that proteomics will play an important role in clinical nephrology in the very near future and that this progress will require interactive dialogue and collaboration between clinicians and analytical specialists. |
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Authors:
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Danilo Fliser; Jan Novak; Visith Thongboonkerd; Angel Argilés; Vera Jankowski; Mark A Girolami; Joachim Jankowski; Harald Mischak |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review Date: 2007-02-28 |
Journal Detail:
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Title: Journal of the American Society of Nephrology : JASN Volume: 18 ISSN: 1046-6673 ISO Abbreviation: J. Am. Soc. Nephrol. Publication Date: 2007 Apr |
Date Detail:
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Created Date: 2007-03-28 Completed Date: 2007-05-31 Revised Date: 2007-12-03 |
Medline Journal Info:
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Nlm Unique ID: 9013836 Medline TA: J Am Soc Nephrol Country: United States |
Other Details:
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Languages: eng Pagination: 1057-71 Citation Subset: IM |
Affiliation:
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Mosaiques Diagnostics and Therapeutics AG, Mellendorfer Strasse 7-9, D-30625 Hannover, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Biological Markers
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urine* Chromatography, Liquid Computational Biology Electrophoresis, Capillary Humans Kidney Diseases / diagnosis*, urine* Mass Spectrometry Nephrology Proteinuria / urine* Proteome* Proteomics Uremia / urine |
| Grant Support | |
ID/Acronym/Agency:
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DK61525/DK/NIDDK NIH HHS; DK71802/DK/NIDDK NIH HHS; M01 RR00032/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Proteome |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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