Document Detail

Advances in understanding the pathogenesis of chronic thromboembolic pulmonary hypertension.
MedLine Citation:
PMID:  20331466     Owner:  NLM     Status:  MEDLINE    
Chronic thromboembolic pulmonary hypertension (CTEPH) comprises organizing thrombotic obstructions in the pulmonary arteries. While roughly 40% of CTEPH cases are not preceded by a venous thromboembolic event, 0.1-5.1% of acute pulmonary thromboemboli evolve into organized obstructions of the pulmonary artery. In patients with predominantly proximal disease, surgical pulmonary endarterectomy provides a potential cure of the disease. For years, the scientific debate of CTEPH was mainly focused around its thromboembolic nature because of striking dissimilarities to classical venous thromboembolism, for example, the lack of risk factors for venous thrombosis, the lack of clinically apparent pulmonary embolism in many patients, the difficulty to reproduce the disease in animal models of thrombosis, and the nature of the pulmonary vascular obstructions that are dissociated from the degree of hemodynamic compromise. Recent studies have confirmed an association between venous thromboembolism and the evolution of CTEPH, and have shed light on disease-modifying conditions.
Irene Lang
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Publication Detail:
Type:  Journal Article; Review     Date:  2010-03-16
Journal Detail:
Title:  British journal of haematology     Volume:  149     ISSN:  1365-2141     ISO Abbreviation:  Br. J. Haematol.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-05-04     Completed Date:  2010-07-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372544     Medline TA:  Br J Haematol     Country:  England    
Other Details:
Languages:  eng     Pagination:  478-83     Citation Subset:  IM    
Division of Cardiology, Department of Internal Medicine II, Vienna General Hospital, Medical University of Vienna, Vienna, Austria.
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MeSH Terms
Chronic Disease
Fibrinogen / physiology
Hypertension, Pulmonary / epidemiology,  etiology*,  surgery
Pulmonary Embolism / complications*
Venous Thromboembolism / complications
Reg. No./Substance:

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