Document Detail

Advances in understanding the mechanisms of migraine-type photophobia.
MedLine Citation:
PMID:  21467933     Owner:  NLM     Status:  MEDLINE    
PURPOSE OF REVIEW: Historically, photophobia was studied in patients and attempts to explain the underlying mechanisms have been speculative. Efforts to understand better the neural substrate of photophobia paved a way to the development of different animal models and the publication of several articles (all in 2010) on the mechanism by which light exacerbates migraine headache.
RECENT FINDINGS: Observations made in blind migraine patients devoid of any visual perception and blind migraine patients capable of detecting light have led to the discovery of a novel retino-thalamo-cortical pathway that carries photic signal from the retina to thalamic trigeminovascular neurons believed to play a critical role in the perception of headache intensity during migraine. Evidence for modulation of the trigeminovascular pathway by light and identification of the pathway through which photic signals converge on the nociceptive pathway that mediates migraine headache provide first set of scientific data on the mechanism by which light intensifies migraine headache.
SUMMARY: The findings provide a neural substrate for migraine-type photophobia. This may lead to identification and development of molecular targets for selective prevention of photophobia during migraine.
Rodrigo Noseda; Rami Burstein
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Current opinion in neurology     Volume:  24     ISSN:  1473-6551     ISO Abbreviation:  Curr. Opin. Neurol.     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-05-02     Completed Date:  2011-08-15     Revised Date:  2013-01-18    
Medline Journal Info:
Nlm Unique ID:  9319162     Medline TA:  Curr Opin Neurol     Country:  England    
Other Details:
Languages:  eng     Pagination:  197-202     Citation Subset:  IM    
Department of Anesthesia and Critical Care, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
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MeSH Terms
Brain / anatomy & histology,  physiology
Calcitonin Gene-Related Peptide / metabolism
Migraine Disorders / complications*
Photophobia / etiology*
Rod Opsins / metabolism
Visual Perception / physiology
Grant Support
Reg. No./Substance:
0/Rod Opsins; 0/melanopsin; 83652-28-2/Calcitonin Gene-Related Peptide

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