Document Detail

Advances in the understanding and classification of pulmonary hypertension.
MedLine Citation:
PMID:  19187180     Owner:  NLM     Status:  MEDLINE    
Pulmonary hypertension has a complex pathobiology and the term pulmonary arterial hypertension (PAH) includes a variety of pulmonary hypertensive diseases that have different aetiologies, but which may have a similar clinical presentation and, in some cases, the same response to medical treatment. More recent classifications have been based on aetiology, functional data and clinical presentation, but morphometric studies have shown differences in the distribution and prevalence of vascular changes amongst cases of PAH of different aetiologies. Recent advances in the understanding of some aspects of the genetic and molecular mechanisms, together with detailed descriptions of the histopathological findings in PAH cases of different aetiologies, should contribute to a better understanding of the relationships of the various subsets of the disease, the prognostic implications and possible treatment options.
Susan Stewart; Doris Rassl
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Histopathology     Volume:  54     ISSN:  1365-2559     ISO Abbreviation:  Histopathology     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2009-02-03     Completed Date:  2009-05-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7704136     Medline TA:  Histopathology     Country:  England    
Other Details:
Languages:  eng     Pagination:  104-16     Citation Subset:  IM    
Department of Histopathology, Papworth Hospital, Papworth Everard, Cambridge, UK.
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MeSH Terms
Hypertension, Pulmonary / classification*,  diagnosis,  pathology*
Pulmonary Circulation / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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