| Advances in understanding the aetiology of atypical Haemolytic Uraemic Syndrome. | |
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MedLine Citation:
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PMID: 20629662 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Atypical Haemolytic Uraemic Syndrome (aHUS) is a thrombotic microangiopathy that often provokes irreversible renal damage and post-transplantation recurrence. Studies performed during the last decade have shown that 50-60% of aHUS patients present genetic or acquired defects in the complement system that enhance the initial endothelial damage and favour disease development. This review analyses the complement proteins and processes that are disturbed in aHUS patients, and outlines the relevance of a prompt genetic/molecular diagnosis for improving clinical management and prognosis. |
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Authors:
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Pilar Sánchez-Corral; Marta Melgosa |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2010-07-14 |
Journal Detail:
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Title: British journal of haematology Volume: 150 ISSN: 1365-2141 ISO Abbreviation: Br. J. Haematol. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-19 Completed Date: 2010-10-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372544 Medline TA: Br J Haematol Country: England |
Other Details:
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Languages: eng Pagination: 529-42 Citation Subset: IM |
Affiliation:
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Research, University Hospital La Paz, Madrid, Spain. psanchez.hulp@salud.madrid.org |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Complement Pathway, Alternative
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genetics,
immunology Genetic Predisposition to Disease Hemolytic-Uremic Syndrome / etiology*, genetics, immunology, therapy Humans Kidney Transplantation Mutation |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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