| Advances in research of fish immune-relevant genes: a comparative overview of innate and adaptive immunity in teleosts. | |
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MedLine Citation:
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PMID: 22504163 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Fish is considered to be an important model in comparative immunology studies because it is a representative population of lower vertebrates serving as an essential link to early vertebrate evolution. Fish immune-relevant genes have received considerable attention due to its role in improving understanding of both fish immunology and the evolution of immune systems. In this review, we discuss the current understanding of teleost immune-relevant genes for both innate and adaptive immunity, including pattern recognition receptors, antimicrobial peptides, complement molecules, lectins, interferons and signaling factors, inflammatory cytokines, chemokines, adaptive immunity relevant cytokines and negative regulators, major histocompatibility complexes, immunoglobulins, and costimulatory molecules. The implications of these factors on the evolutionary history of immune systems were discussed and a perspective outline of innate and adaptive immunity of teleost fish was described. This review may provide clues on the evolution of the essential defense system in vertebrates. |
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Authors:
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Lv-Yun Zhu; Li Nie; Guan Zhu; Li-Xing Xiang; Jian-Zhong Shao |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-4-12 |
Journal Detail:
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Title: Developmental and comparative immunology Volume: - ISSN: 1879-0089 ISO Abbreviation: - Publication Date: 2012 Apr |
Date Detail:
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Created Date: 2012-4-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7708205 Medline TA: Dev Comp Immunol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012. Published by Elsevier Ltd. |
Affiliation:
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College of Life Sciences, Zhejiang University, Hangzhou 310058, People's Republic of China;Key Laboratory for Cell and Gene Engineering of Zhejiang Province, Hangzhou 310058, People's Republic of China;Key Laboratory of Animal Virology of Ministry of Agriculture, Hangzhou 310058, People's Republic of China. |
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