Document Detail

Advances in prostanoid infusion therapy for pulmonary arterial hypertension.
MedLine Citation:
PMID:  19018187     Owner:  NLM     Status:  MEDLINE    
Pulmonary arterial hypertension is a rare but progressive and life-threatening disease that presents considerable challenges for both the patient and the caregiver. Though complex, intravenous epoprostenol and treprostinil may improve long-term survival, exercise capacity, hemodynamics, and other clinical symptoms of pulmonary arterial hypertension. Recent advances in infusion pump technology offer ambulatory pump sizes as small as a pager and continuous infusion flow rates as low as 0.1 mL/h, which may provide quality-of-life advantages for patients treated with treprostinil. Transition methods from epoprostenol to treprostinil vary and require close patient monitoring for up to several months. Patients and clinicians must be aware of the differences among delivery systems and the potential for adverse events.
Aimee Doran; Stephanie Harris; Brett Goetz
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of infusion nursing : the official publication of the Infusion Nurses Society     Volume:  31     ISSN:  1539-0667     ISO Abbreviation:  J Infus Nurs     Publication Date:    2008 Nov-Dec
Date Detail:
Created Date:  2008-11-21     Completed Date:  2009-01-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101124170     Medline TA:  J Infus Nurs     Country:  United States    
Other Details:
Languages:  eng     Pagination:  336-45     Citation Subset:  N    
Pulmonary Hypertension Program, The Children's Hospital, Aurora, Colorado, USA.
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MeSH Terms
Epoprostenol / administration & dosage*,  analogs & derivatives*,  therapeutic use
Hypertension, Pulmonary / drug therapy*
Infusion Pumps
Infusions, Intravenous
Monitoring, Physiologic
Reg. No./Substance:
0/treprostinil; 35121-78-9/Epoprostenol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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