Document Detail


Advances in predicting acute GVHD.
MedLine Citation:
PMID:  23205489     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Acute graft-versus-host disease (GVHD) is a leading cause of non-relapse mortality following allogeneic haematopoietic cell transplantation. Attempts to improve treatment response in clinically-established GVHD have not improved overall survival, often due to the increased risk of infectious complications. Alternative approaches to decrease GVHD-related morbidity and mortality have focused on the ability to predict GVHD prior to clinical manifestation in an effort to provide an opportunity to abort GVHD development, and to gain new insights into GVHD pathophysiology. This review outlines the research efforts to date that have identified clinical and laboratory-based factors that are predictive of acute GVHD and describes future directions in developing algorithms that will improve the ability to predict the development of clinically relevant GVHD.
Authors:
Andrew C Harris; James L M Ferrara; John E Levine
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2012-12-04
Journal Detail:
Title:  British journal of haematology     Volume:  160     ISSN:  1365-2141     ISO Abbreviation:  Br. J. Haematol.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-21     Completed Date:  2013-06-14     Revised Date:  2014-02-04    
Medline Journal Info:
Nlm Unique ID:  0372544     Medline TA:  Br J Haematol     Country:  England    
Other Details:
Languages:  eng     Pagination:  288-302     Citation Subset:  IM    
Copyright Information:
© 2012 Blackwell Publishing Ltd.
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Biological Markers / blood
Graft vs Host Disease / diagnosis*,  etiology*
Hematopoietic Stem Cell Transplantation / adverse effects
Humans
Prognosis
Risk Factors
Transplantation Conditioning
Transplantation, Homologous
Transplants
Grant Support
ID/Acronym/Agency:
P01 CA039542/CA/NCI NIH HHS; P01-CA039542/CA/NCI NIH HHS; U10 HL069330/HL/NHLBI NIH HHS; U10-HL069330/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Biological Markers
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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