| Advances in pharmacologic agents in imaging: new A2A receptor agonists. | |
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MedLine Citation:
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PMID: 16524538 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pharmacologic stress myocardial perfusion imaging is being performed with increasing frequency over exercise stress. Dipyridamole and adenosine have a high side-effect profile, provide higher than needed coronary artery flow rates, and use a relatively complicated method of administration. Based on preclinical animal work, three selective adenosine A2A receptor agonists, regadenoson (CVT3146), binodenoson (MRE0470 or WRC0470), and apadenoson (BMS068645 or ATL146e), may overcome these limitations and are now in Phase III studies as pharmacologic stress agents. For single-photon emission CT imaging, binodenoson and regadenoson were concordant with adenosine images for detection and quantitation of ischemia. Despite the high A2A selectivity of binodenoson and regadenoson in preclinical studies, subjective side effects attributable to other adenosine receptor subtypes were still observed in human studies and are similar to or slightly lower than adenosine. There have been no reports of atrioventricular block or bronchospasm with either regadenoson or binodenoson in published trials. |
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Authors:
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Manuel D Cerqueira |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Current cardiology reports Volume: 8 ISSN: 1523-3782 ISO Abbreviation: Curr Cardiol Rep Publication Date: 2006 Mar |
Date Detail:
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Created Date: 2006-03-09 Completed Date: 2007-09-24 Revised Date: 2013-06-03 |
Medline Journal Info:
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Nlm Unique ID: 100888969 Medline TA: Curr Cardiol Rep Country: United States |
Other Details:
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Languages: eng Pagination: 119-22 Citation Subset: IM |
Affiliation:
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Department of Molecular and Functional Imaging (Gb3), Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA. cerquem@ccf.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine
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analogs & derivatives,
diagnostic use Adenosine A2 Receptor Agonists* Coronary Vessels / drug effects*, radionuclide imaging Cyclohexanecarboxylic Acids / diagnostic use Dipyridamole / diagnostic use Heart / radionuclide imaging* Humans Organotechnetium Compounds / diagnostic use Purines / diagnostic use Pyrazoles / diagnostic use Tomography, Emission-Computed, Single-Photon / methods* Vasodilator Agents / diagnostic use* |
| Chemical | |
Reg. No./Substance:
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0/ATL 146e; 0/Adenosine A2 Receptor Agonists; 0/Cyclohexanecarboxylic Acids; 0/Organotechnetium Compounds; 0/Purines; 0/Pyrazoles; 0/Vasodilator Agents; 0/regadenoson; 58-32-2/Dipyridamole; 58-61-7/Adenosine; LJA4M1L5LG/binodenoson |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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