| Advances in pediatric restless legs syndrome: Iron, genetics, diagnosis and treatment. | |
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MedLine Citation:
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PMID: 20620105 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A substantial literature characterizes pediatric restless legs syndrome (RLS), which occurs in about 1.9% of individuals between 8 and 18years of age. Diagnostic interview techniques and an updated inventory of pediatric RLS mimics are presented. Evidence for comorbidity of pediatric RLS with attention-deficit/hyperactivity disorder, depression, and anxiety is reviewed as is the relationship to periodic limb movements in sleep and periodic limb movement disorder. The role of relative iron deficiency in pediatric RLS is discussed, along with new data indicating the benefit of iron therapy in reducing symptoms. Five genetic variants have been linked to RLS, an important finding in a condition that is highly familial in early-onset cases. Numerous case reports and case series indicate benefit for moderate to severe pediatric RLS with medication. However, to date, there have been no double-blind, placebo-controlled studies of therapy for pediatric RLS published. These and other recent advances relevant to pediatric RLS research are reviewed. |
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Authors:
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Matthew A Picchietti; Daniel L Picchietti |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Sleep medicine Volume: 11 ISSN: 1878-5506 ISO Abbreviation: Sleep Med. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-23 Completed Date: 2010-11-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100898759 Medline TA: Sleep Med Country: Netherlands |
Other Details:
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Languages: eng Pagination: 643-51 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier B.V. All rights reserved. |
Affiliation:
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Department of Psychology, Southern Illinois University, Carbondale, IL 62901, USA. picchima@siu.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Attention Deficit Disorder with Hyperactivity
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epidemiology Child Comorbidity Diagnosis, Differential Genetic Predisposition to Disease / epidemiology* Humans Iron / blood*, therapeutic use* Restless Legs Syndrome* / diagnosis, drug therapy, epidemiology |
| Grant Support | |
ID/Acronym/Agency:
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R01 NS4 0829-02/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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7439-89-6/Iron |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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