Document Detail

Advances in the pathogenesis and management of hypertensive crisis.
MedLine Citation:
PMID:  15800414     Owner:  NLM     Status:  MEDLINE    
PURPOSE OF REVIEW: This review summarizes recent insights into to the pathophysiology of hypertensive crisis with the emphasis on newly discovered molecular mechanisms underlying hypertension and also updates current therapeutic options for treating hypertensive crisis in children. RECENT FINDINGS: There is growing evidence that the renin-angiotensin system plays a key role in the pathogenesis of hypertensive crises. Recent studies have shown that oxidative stress and factors affecting endothelial function are also important. Treatment of hypertensive crisis still focuses on lowering of blood pressure in an expeditious but safe manner. There is growing experience with IV nicardipine, which is becoming a viable alternative to sodium nitroprusside in children. SUMMARY: Current knowledge of hypertensive crisis emphasizes the need for additional animal and translational studies with the goal of identifying the underlying molecular pathogenesis and developing new therapies to optimize future treatment of hypertensive emergencies.
Hiren P Patel; Mark Mitsnefes
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in pediatrics     Volume:  17     ISSN:  1040-8703     ISO Abbreviation:  Curr. Opin. Pediatr.     Publication Date:  2005 Apr 
Date Detail:
Created Date:  2005-03-31     Completed Date:  2005-12-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9000850     Medline TA:  Curr Opin Pediatr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  210-4     Citation Subset:  IM    
Department of Pediatrics, Children's Hospital, The Ohio State University School of Medicine and Public Health, Columbus, Ohio, USA.
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MeSH Terms
Antihypertensive Agents / therapeutic use*
Blood Pressure / drug effects,  physiology
Endothelium, Vascular / drug effects,  physiopathology
Hypertension / drug therapy*,  etiology,  physiopathology
Oxidative Stress / drug effects,  physiology
Renin-Angiotensin System / drug effects,  physiology
Reg. No./Substance:
0/Antihypertensive Agents

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