| Advances in the pathogenesis, diagnosis and treatment of thrombotic thrombocytopenic purpura and hemolytic uremic syndrome. | |
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MedLine Citation:
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PMID: 16126255 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The thrombotic microangiopathies are microvascular occlusive disorders characterized by hemolytic anemia caused by fragmentation of erythrocytes and thrombocytopenia due to increased platelet aggregation and thrombus formation, eventually leading to disturbed microcirculation with reduced organ perfusion. Depending on whether brain or renal lesions prevail, two different entities have been described: thrombotic thrombocytopenic purpura (TTP) and hemolytic uremic syndrome (HUS). However, not rarely the clinical distinctions between these two conditions remain questionable. Recent studies have contributed greatly to our current understanding of the molecular mechanisms leading to TTP and HUS. In this review, we briefly focus on the most important advances in the pathophysiology, diagnosis and treatment of these two thrombotic microangiopathies. |
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Authors:
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Massimo Franchini; Marco Zaffanello; Dino Veneri |
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Publication Detail:
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Type: Journal Article; Review Date: 2005-08-29 |
Journal Detail:
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Title: Thrombosis research Volume: 118 ISSN: 0049-3848 ISO Abbreviation: Thromb. Res. Publication Date: 2006 |
Date Detail:
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Created Date: 2006-06-08 Completed Date: 2006-08-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0326377 Medline TA: Thromb Res Country: United States |
Other Details:
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Languages: eng Pagination: 177-84 Citation Subset: IM |
Affiliation:
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Servizio di Immunoematologia e Trasfusione, Ospedale Policlinico, Piazzale L. Scuro Azienda Ospedaliera di Verona, Italy. mfranchini@mail.univr.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Hemolytic-Uremic Syndrome*
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diagnosis,
etiology,
therapy Humans Purpura, Thrombotic Thrombocytopenic* / diagnosis, etiology, therapy Syndrome |
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