Document Detail


Advances in nanotechnology for the management of coronary artery disease.
MedLine Citation:
PMID:  23245913     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Nanotechnology holds tremendous potential to advance the current treatment of coronary artery disease. Nanotechnology may assist medical therapies by providing a safe and efficacious delivery platform for a variety of drugs aimed at modulating lipid disorders, decreasing inflammation and angiogenesis within atherosclerotic plaques, and preventing plaque thrombosis. Nanotechnology may improve coronary stent applications by promoting endothelial recovery on a stent surface utilizing bio-mimetic nanofibrous scaffolds, and also by preventing in-stent restenosis using nanoparticle-based delivery of drugs that are decoupled from stents. Additionally, nanotechnology may enhance tissue-engineered graft materials for application in coronary artery bypass grafting by facilitating cellular infiltration and remodeling of a graft matrix.
Authors:
June-Wha Rhee; Joseph C Wu
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2012-12-13
Journal Detail:
Title:  Trends in cardiovascular medicine     Volume:  23     ISSN:  1873-2615     ISO Abbreviation:  Trends Cardiovasc. Med.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-02-06     Completed Date:  2013-07-30     Revised Date:  2014-02-04    
Medline Journal Info:
Nlm Unique ID:  9108337     Medline TA:  Trends Cardiovasc Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  39-45     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Blood Vessel Prosthesis
Coronary Artery Disease / therapy*
Drug Delivery Systems
Humans
Nanotechnology / methods*
Percutaneous Coronary Intervention / methods
Stents
Grant Support
ID/Acronym/Agency:
R01 EB009689/EB/NIBIB NIH HHS; R01 HL093172/HL/NHLBI NIH HHS; R01 HL095571/HL/NHLBI NIH HHS; R01EB009689/EB/NIBIB NIH HHS; R01HL093172/HL/NHLBI NIH HHS; R01HL095571/HL/NHLBI NIH HHS; R21 HL089027/HL/NHLBI NIH HHS; R33 HL089027/HL/NHLBI NIH HHS; R33HL089027/HL/NHLBI NIH HHS
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