| Advances in the management of meconium aspiration syndrome. | |
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MedLine Citation:
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PMID: 22164183 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Meconium aspiration syndrome (MAS) is a common cause of severe respiratory distress in term infants, with an associated highly variable morbidity and mortality. MAS results from aspiration of meconium during intrauterine gasping or during the first few breaths. The pathophysiology of MAS is multifactorial and includes acute airway obstruction, surfactant dysfunction or inactivation, chemical pneumonitis with release of vasoconstrictive and inflammatory mediators, and persistent pulmonary hypertension of newborn (PPHN). This disorder can be life threatening, often complicated by respiratory failure, pulmonary air leaks, and PPHN. Approaches to the prevention of MAS have changed over time with collaboration between obstetricians and pediatricians forming the foundations for care. The use of surfactant and inhaled nitric oxide (iNO) has led to the decreased mortality and the need for extracorporeal membrane oxygenation (ECMO) use. In this paper, we review the current understanding of the pathophysiology and management of MAS. |
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Authors:
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Kamala Swarnam; Amuchou S Soraisham; Sindhu Sivanandan |
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Publication Detail:
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Type: Journal Article Date: 2011-11-22 |
Journal Detail:
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Title: International journal of pediatrics Volume: 2012 ISSN: 1687-9759 ISO Abbreviation: Int J Pediatr Publication Date: 2012 |
Date Detail:
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Created Date: 2011-12-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101517077 Medline TA: Int J Pediatr Country: Egypt |
Other Details:
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Languages: eng Pagination: 359571 Citation Subset: - |
Affiliation:
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Division of Neonatology, Department of Pediatrics, University of Calgary, Calgary, AB, Canada T2N 1N4. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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