Document Detail

Advances in the management of alloimmune thrombocytopenia.
MedLine Citation:
PMID:  17233844     Owner:  NLM     Status:  MEDLINE    
There have been considerable advances in the clinical and laboratory diagnosis of alloimmune thrombocytopenia (AIT), and its postnatal and antenatal management. The antenatal management of AIT has been particularly problematic, because severe haemorrhage occurs as early as 16 weeks gestation and there is no non-invasive investigation that reliably predicts the severity of AIT in utero. The strategies for antenatal treatment have included the use of serial platelet transfusions that, while effective, are invasive and associated with significant morbidity and mortality. Maternal therapy involving the administration of intravenous immunoglobulin and/or steroids is also effective and associated with fewer risks to the fetus. Significant recent progress has involved refinement of maternal treatment, stratifying it according to the likely severity of AIT based on the history in previous pregnancies. However, the ideal antenatal treatment, which is effective without causing significant side-effects to the mother or fetus, has yet to be determined, and further clinical trials are needed.
Michael F Murphy; James B Bussel
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  British journal of haematology     Volume:  136     ISSN:  0007-1048     ISO Abbreviation:  Br. J. Haematol.     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-01-19     Completed Date:  2007-03-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372544     Medline TA:  Br J Haematol     Country:  England    
Other Details:
Languages:  eng     Pagination:  366-78     Citation Subset:  IM    
National Blood Service, Department of Haematology, John Radcliffe Hospital, University of Oxford, Oxford, UK.
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MeSH Terms
Blood Transfusion, Intrauterine
Cost-Benefit Analysis
Fetal Diseases / diagnosis*,  immunology,  therapy
Glucocorticoids / therapeutic use
Immunoglobulins, Intravenous
Infant, Newborn
Platelet Transfusion
Pregnancy Complications, Hematologic / diagnosis*,  immunology,  therapy
Prenatal Diagnosis / methods
Thrombocytopenia / diagnosis*,  immunology,  therapy
Reg. No./Substance:
0/Glucocorticoids; 0/Immunoglobulins, Intravenous

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